Cellosaurus cell line KP-L-RY (CVCL

Cellosaurus KP-L-RY (CVCL_7984)

Cross-references
Cell line name	KP-L-RY
Synonyms	KPL-RY; K.P.L.RY; KPLRY; Kyoto Pediatrics-Leukemia-RY
Accession	CVCL_7984
Resource Identification Initiative	To cite this cell line use: KP-L-RY (RRID:CVCL_7984)
Comments	Population: Japanese. Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Gene fusion; HGNC; HGNC:17869; AFF4 + HGNC; HGNC:7132; KMT2A; Name(s)=KMT2A-AFF4, MLL-AF5Q31 (PubMed=12399976; PubMed=14671638).
Disease	Childhood B acute lymphoblastic leukemia (NCIt: C9140) B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged (NCIt: C80342) B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) (ORDO: Orphanet_585918)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	1M
Category	Cancer cell line
Publications	PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4 Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J. Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines. Leuk. Res. 24:255-262(2000) PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1 Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J. Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262. Leuk. Res. 25:275-278(2001) PubMed=12399976; DOI=10.1038/sj.leu.2402665 Imamura T., Morimoto A., Ikushima S., Kakazu N., Hada S., Tabata Y., Yagi T., Inaba T., Hibi S., Sugimoto T., Imashuku S. A novel infant acute lymphoblastic leukemia cell line with MLL-AF5q31 fusion transcript. Leukemia 16:2302-2308(2002) PubMed=14671638; DOI=10.1038/sj.leu.2403236 Drexler H.G., Quentmeier H., MacLeod R.A.F. Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations. Leukemia 18:227-232(2004)
Encyclopedic resources	Wikidata; Q54900380
Experimental variables resources	EFO; EFO_0022444
Polymorphism and mutation databases	Cosmic; 2378133
Entry history
Entry creation	04-Apr-2012
Last entry update	19-Dec-2024
Version number	20