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Cellosaurus UM-SCC-1 (CVCL_7707)

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Cell line name UM-SCC-1
Synonyms UMSCC-1; UM-SCC1; UMSCC1; SCC-1; SCC1; University of Michigan-Squamous Cell Carcinoma-1
Accession CVCL_7707
Resource Identification Initiative To cite this cell line use: UM-SCC-1 (RRID:CVCL_7707)
Comments Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by RNAseq.
Caution: Indicated as originating from a 60 year old patient in PubMed=3855324 and from a 72 year old in PubMed=1851275 and PubMed=18006756.
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Sequence variations
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_L893 (1Cc8)CVCL_4V02 (SCC-1-Cet-R)CVCL_4V03 (SCC-1-Erl-R)
CVCL_4V04 (SCC-1-Gef-R)CVCL_1Q88 (T409)CVCL_4912 (Tu 167)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): Millipore; PubMed=19760794; PubMed=21868764

AmelogeninX (PubMed=19760794_passage_150; PubMed=21868764)
X,Y (Millipore; PubMed=19760794_passage_4)
D8S117913,16 (Millipore; PubMed=19760794_passage_4)
16 (PubMed=19760794_passage_150)
FGA18 (PubMed=19760794_passage_150)
18,22 (PubMed=19760794_passage_4)
22 (Millipore)
Penta D9
Penta E13

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/

PubMed=3855324; DOI=10.1288/00005537-198501000-00012
Baker S.R.
An in vivo model for squamous cell carcinoma of the head and neck.
Laryngoscope 95:43-56(1985)

PubMed=1851275; DOI=10.1177/019459989110400304
Bradford C.R., Zacks S.E., Androphy E.J., Gregoire L., Lancaster W.D., Carey T.E.
Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas.
Otolaryngol. Head Neck Surg. 104:303-310(1991)

Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=8725545; DOI=10.3109/00016489609137854
Pekkola-Heino K., Servomaa K., Kiuru A., Grenman R.
Increased radiosensitivity is associated with p53 mutations in cell lines derived from oral cavity carcinoma.
Acta Oto-Laryngol. 116:341-344(1996)

PubMed=8782485; DOI=10.1046/j.1365-2184.1996.01009.x
Servomaa K., Kiuru A., Grenman R., Pekkola-Heino K., Pulkkinen J.O., Rytomaa T.
p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines.
Cell Prolif. 29:219-230(1996)

PubMed=12884349; DOI=10.1002/hed.10274
Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A., Johnson G., Wolf G.T., Fisher S.G., Carey T.E.
P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.
Head Neck 25:654-661(2003)

PubMed=17312569; DOI=10.1002/hed.20478
Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y.
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=18006756; DOI=10.1158/1078-0432.CCR-07-1591
Friedman J., Nottingham L., Duggal P., Pernas F.G., Yan B., Yang X.-P., Chen Z., Van Waes C.
Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer.
Clin. Cancer Res. 13:6568-6578(2007)

PubMed=19760794; DOI=10.1002/hed.21198
Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R., Lyons R.H., Bradford C.R., Carey T.E.
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4
Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S., Ito Y., Myers J.N., Oridate N.
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30527230; DOI=10.1016/j.oraloncology.2018.10.031
Ludwig M.L., Kulkarni A., Birkeland A.C., Michmerhuizen N.L., Foltin S.K., Mann J.E., Hoesli R.C., Devenport S.N., Jewell B.M., Shuman A.G., Spector M.E., Carey T.E., Jiang H., Brenner J.C.
The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines.
Oral Oncol. 87:144-151(2018)

Cell line collections (Providers) Millipore; SCC070
Cell line databases/resources cancercelllines; CVCL_7707
Anatomy/cell type resources BTO; BTO:0003138
Chemistry resources ChEMBL-Cells; CHEMBL3707167
ChEMBL-Targets; CHEMBL3707168
PubChem_Cell_line; CVCL_7707
Encyclopedic resources Wikidata; Q54990789
Gene expression databases GEO; GSM3631262
Polymorphism and mutation databases Cosmic; 1483455
Cosmic; 1530751
Cosmic; 2131858
IARC_TP53; 21100
Progenetix; CVCL_7707
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number28