Cellosaurus logo
expasy logo

Cellosaurus SYO-1 (CVCL_7146)

[Text version]
Cell line name SYO-1
Synonyms SYO-I; SYO1
Accession CVCL_7146
Resource Identification Initiative To cite this cell line use: SYO-1 (RRID:CVCL_7146)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: 28 hours (PubMed=14744540).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Groin; UBERON=UBERON_0008337.
Sequence variations
  • Gene fusion; HGNC; 11340; SS18 + HGNC; 11336; SSX2; Name(s)=SS18-SSX2 (PubMed=14744540; DepMap).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly34Val (c.101G>T); ClinVar=VCV000017582; Zygosity=Unspecified (DepMap).
Disease Biphasic synovial sarcoma (NCIt: C4279)
Synovial sarcoma (ORDO: Orphanet_3273)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=14744540; DOI=10.1016/j.canlet.2003.09.031
Kawai A., Naito N., Yoshida A., Morimoto Y., Ouchida M., Shimizu K., Beppu Y.
Establishment and characterization of a biphasic synovial sarcoma cell line, SYO-1.
Cancer Lett. 204:105-113(2004)

PubMed=24726063; DOI=10.1186/1756-9966-33-33
Koelsche C., Renner M., Hartmann W., Brandt R., Lehner B., Waldburger N., Alldinger I., Schmitt T., Egerer G., Penzel R., Wardelmann E., Schirmacher P., von Deimling A., Mechtersheimer G.
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=27353471; DOI=10.1111/gtc.12387
Yamasaki H., Miyamoto M., Yamamoto Y., Kondo T., Watanabe T., Ohta T.
Synovial sarcoma cell lines showed reduced DNA repair activity and sensitivity to a PARP inhibitor.
Genes Cells 21:852-860(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7146
Cell_Model_Passport; SIDM01453
DepMap; ACH-001275
Chemistry resources PharmacoDB; SYO1_1553_2019
Encyclopedic resources Wikidata; Q54971281
Gene expression databases GEO; GSM482570
GEO; GSM1676335
GEO; GSM1701667
GEO; GSM2887622
GEO; GSM2887623
Polymorphism and mutation databases Cosmic; 1211854
Cosmic; 1319812
Cosmic; 2307725
Progenetix; CVCL_7146
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23