ID   SYO-1
AC   CVCL_7146
SY   SYO-I; SYO1
DR   cancercelllines; CVCL_7146
DR   Cell_Model_Passport; SIDM01453
DR   Cosmic; 1211854
DR   Cosmic; 1319812
DR   Cosmic; 2307725
DR   DepMap; ACH-001275
DR   GEO; GSM482570
DR   GEO; GSM1676335
DR   GEO; GSM1701667
DR   GEO; GSM2887622
DR   GEO; GSM2887623
DR   PharmacoDB; SYO1_1553_2019
DR   Progenetix; CVCL_7146
DR   Wikidata; Q54971281
RX   PubMed=14744540;
RX   PubMed=24726063;
RX   PubMed=26351324;
RX   PubMed=27353471;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Japanese.
CC   Doubling time: 28 hours (PubMed=14744540).
CC   Sequence variation: Gene fusion; HGNC; 11340; SS18 + HGNC; 11336; SSX2; Name(s)=SS18-SSX2 (PubMed=14744540; DepMap).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly34Val (c.101G>T); ClinVar=VCV000017582; Zygosity=Unspecified (DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Groin; UBERON=UBERON_0008337.
DI   NCIt; C4279; Biphasic synovial sarcoma
DI   ORDO; Orphanet_3273; Synovial sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   19Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 23
//
RX   PubMed=14744540; DOI=10.1016/j.canlet.2003.09.031;
RA   Kawai A., Naito N., Yoshida A., Morimoto Y., Ouchida M., Shimizu K.,
RA   Beppu Y.;
RT   "Establishment and characterization of a biphasic synovial sarcoma
RT   cell line, SYO-1.";
RL   Cancer Lett. 204:105-113(2004).
//
RX   PubMed=24726063; DOI=10.1186/1756-9966-33-33;
RA   Koelsche C., Renner M., Hartmann W., Brandt R., Lehner B.,
RA   Waldburger N., Alldinger I., Schmitt T., Egerer G., Penzel R.,
RA   Wardelmann E., Schirmacher P., von Deimling A., Mechtersheimer G.;
RT   "TERT promoter hotspot mutations are recurrent in myxoid liposarcomas
RT   but rare in other soft tissue sarcoma entities.";
RL   J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014).
//
RX   PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074;
RA   Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E.,
RA   Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J.,
RA   Harris E., Monks A., Morris J.;
RT   "Sarcoma cell line screen of oncology drugs and investigational agents
RT   identifies patterns associated with gene and microRNA expression.";
RL   Mol. Cancer Ther. 14:2452-2462(2015).
//
RX   PubMed=27353471; DOI=10.1111/gtc.12387;
RA   Yamasaki H., Miyamoto M., Yamamoto Y., Kondo T., Watanabe T., Ohta T.;
RT   "Synovial sarcoma cell lines showed reduced DNA repair activity and
RT   sensitivity to a PARP inhibitor.";
RL   Genes Cells 21:852-860(2016).
//