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Cellosaurus SQ-20B (CVCL_7138)

[Text version]
Cell line name SQ-20B
Synonyms SQ20B; SQ20-B
Accession CVCL_7138
Resource Identification Initiative To cite this cell line use: SQ-20B (RRID:CVCL_7138)
Comments Omics: Transcriptome analysis by microarray.
Misspelling: SQ2013; Cosmic=1530760.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=8339273).
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_EI29 (ER-SQ20B)CVCL_D774 (SQD9)CVCL_D775 (SQG6)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=3458227; DOI=10.1073/pnas.83.8.2684; PMCID=PMC323364
Weichselbaum R.R., Dahlberg W.K., Beckett M.A., Karrison T., Miller D., Clark J., Ervin T.J.
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.
Proc. Natl. Acad. Sci. U.S.A. 83:2684-2688(1986)

PubMed=3616625; DOI=10.1126/science.3616625
Kasid U.N., Pfeifer A.M.A., Weichselbaum R.R., Dritschilo A., Mark G.E. 3rd
The raf oncogene is associated with a radiation-resistant human laryngeal cancer.
Science 237:1039-1041(1987)

PubMed=3182330; DOI=10.1016/0360-3016(88)90125-3
Schwartz J.L., Rotmensch J., Giovanazzi S., Cohen M.B., Weichselbaum R.R.
Faster repair of DNA double-strand breaks in radioresistant human tumor cells.
Int. J. Radiat. Oncol. Biol. Phys. 15:907-912(1988)

PubMed=3417487; DOI=10.1016/0360-3016(88)90297-0
Weichselbaum R.R., Beckett M.A., Schwartz J.L., Dritschilo A.
Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy.
Int. J. Radiat. Oncol. Biol. Phys. 15:575-579(1988)

PubMed=2466340; DOI=10.1126/science.2466340
Kasid U.N., Pfeifer A.M.A., Brennan T., Beckett M.A., Weichselbaum R.R., Dritschilo A., Mark G.E. 3rd
Effect of antisense c-raf-1 on tumorigenicity and radiation sensitivity of a human squamous carcinoma.
Science 243:1354-1356(1989)

PubMed=2573646; DOI=10.1080/09553008914551731
Weichselbaum R.R., Rotmensch J., Ahmed-Swan S., Beckett M.A.
Radiobiological characterization of 53 human tumor cell lines.
Int. J. Radiat. Biol. 56:553-560(1989)

PubMed=2380097; DOI=10.1016/0360-3016(90)90136-8
Hallahan D.E., Beckett M.A., Kufe D.W., Weichselbaum R.R.
The interaction between recombinant human tumor necrosis factor and radiation in 13 human tumor cell lines.
Int. J. Radiat. Oncol. Biol. Phys. 19:69-74(1990)

PubMed=1423286
Jung M., Notario V., Dritschilo A.
Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells.
Cancer Res. 52:6390-6393(1992)

PubMed=1574572; DOI=10.2307/3578273
Dunphy E.J., Beckett M.A., Thompson L.H., Weichselbaum R.R.
Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines.
Radiat. Res. 130:166-170(1992)

PubMed=8339273
Brachman D.G., Beckett M.A., Graves D., Haraf D., Vokes E.E., Weichselbaum R.R.
p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.
Cancer Res. 53:3667-3669(1993)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=7938462; DOI=10.2307/3578897
Smeets M.F.M.A., Dahmen-Mooren E.H.M., Abdel-Wahab A.H.A., Bartelink H., Begg A.C.
Differential repair of radiation-induced DNA damage in cells of human squamous cell carcinoma and the effect of caffeine and cysteamine on induction and repair of DNA double-strand breaks.
Radiat. Res. 140:153-160(1994)

PubMed=17312569; DOI=10.1002/hed.20478
Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y.
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Yarbrough W.G., Whigham A., Brown B., Roach M., Slebos R.J.C.
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=25888065; DOI=10.1016/j.molonc.2015.03.008; PMCID=PMC4523436
Stanam A., Love-Homan L., Joseph T.S., Espinosa-Cotton M., Simons A.L.
Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma.
Mol. Oncol. 9:1371-1383(2015)

Cross-references
Cell line collections (Providers) Millipore; SCC287
Cell line databases/resources cancercelllines; CVCL_7138
TOKU-E; 4134
Chemistry resources ChEMBL-Cells; CHEMBL3307460
ChEMBL-Targets; CHEMBL614939
PubChem_Cell_line; CVCL_7138
Encyclopedic resources Wikidata; Q54955598
Gene expression databases GEO; GSM1524316
GEO; GSM1524317
GEO; GSM1524318
Polymorphism and mutation databases Cosmic; 1122674
Cosmic; 1530760
Cosmic; 1530761
IARC_TP53; 6406
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25