ID   SQ-20B
AC   CVCL_7138
SY   SQ20B; SQ20-B
DR   cancercelllines; CVCL_7138
DR   ChEMBL-Cells; CHEMBL3307460
DR   ChEMBL-Targets; CHEMBL614939
DR   Cosmic; 1122674
DR   Cosmic; 1530760
DR   Cosmic; 1530761
DR   GEO; GSM1524316
DR   GEO; GSM1524317
DR   GEO; GSM1524318
DR   IARC_TP53; 6406
DR   Millipore; SCC287
DR   PubChem_Cell_line; CVCL_7138
DR   TOKU-E; 4134
DR   Wikidata; Q54955598
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1423286;
RX   PubMed=1574572;
RX   PubMed=2380097;
RX   PubMed=2466340;
RX   PubMed=2573646;
RX   PubMed=3182330;
RX   PubMed=3417487;
RX   PubMed=3458227;
RX   PubMed=3616625;
RX   PubMed=7938462;
RX   PubMed=8339273;
RX   PubMed=17312569;
RX   PubMed=17848307;
RX   PubMed=25888065;
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=8339273).
CC   Omics: Transcriptome analysis by microarray.
CC   Misspelling: SQ2013; Cosmic=1530760.
CC   Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 25
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).
//
RX   PubMed=1423286;
RA   Jung M., Notario V., Dritschilo A.;
RT   "Mutations in the p53 gene in radiation-sensitive and -resistant human
RT   squamous carcinoma cells.";
RL   Cancer Res. 52:6390-6393(1992).
//
RX   PubMed=1574572; DOI=10.2307/3578273;
RA   Dunphy E.J., Beckett M.A., Thompson L.H., Weichselbaum R.R.;
RT   "Expression of the polymorphic human DNA repair gene XRCC1 does not
RT   correlate with radiosensitivity in the cells of human head and neck
RT   tumor cell lines.";
RL   Radiat. Res. 130:166-170(1992).
//
RX   PubMed=2380097; DOI=10.1016/0360-3016(90)90136-8;
RA   Hallahan D.E., Beckett M.A., Kufe D.W., Weichselbaum R.R.;
RT   "The interaction between recombinant human tumor necrosis factor and
RT   radiation in 13 human tumor cell lines.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 19:69-74(1990).
//
RX   PubMed=2466340; DOI=10.1126/science.2466340;
RA   Kasid U.N., Pfeifer A.M.A., Brennan T., Beckett M.A., Weichselbaum R.R.,
RA   Dritschilo A., Mark G.E. 3rd;
RT   "Effect of antisense c-raf-1 on tumorigenicity and radiation
RT   sensitivity of a human squamous carcinoma.";
RL   Science 243:1354-1356(1989).
//
RX   PubMed=2573646; DOI=10.1080/09553008914551731;
RA   Weichselbaum R.R., Rotmensch J., Ahmed-Swan S., Beckett M.A.;
RT   "Radiobiological characterization of 53 human tumor cell lines.";
RL   Int. J. Radiat. Biol. 56:553-560(1989).
//
RX   PubMed=3182330; DOI=10.1016/0360-3016(88)90125-3;
RA   Schwartz J.L., Rotmensch J., Giovanazzi S., Cohen M.B.,
RA   Weichselbaum R.R.;
RT   "Faster repair of DNA double-strand breaks in radioresistant human
RT   tumor cells.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 15:907-912(1988).
//
RX   PubMed=3417487; DOI=10.1016/0360-3016(88)90297-0;
RA   Weichselbaum R.R., Beckett M.A., Schwartz J.L., Dritschilo A.;
RT   "Radioresistant tumor cells are present in head and neck carcinomas
RT   that recur after radiotherapy.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 15:575-579(1988).
//
RX   PubMed=3458227; DOI=10.1073/pnas.83.8.2684; PMCID=PMC323364;
RA   Weichselbaum R.R., Dahlberg W.K., Beckett M.A., Karrison T., Miller D.,
RA   Clark J., Ervin T.J.;
RT   "Radiation-resistant and repair-proficient human tumor cells may be
RT   associated with radiotherapy failure in head- and neck-cancer
RT   patients.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:2684-2688(1986).
//
RX   PubMed=3616625; DOI=10.1126/science.3616625;
RA   Kasid U.N., Pfeifer A.M.A., Weichselbaum R.R., Dritschilo A.,
RA   Mark G.E. 3rd;
RT   "The raf oncogene is associated with a radiation-resistant human
RT   laryngeal cancer.";
RL   Science 237:1039-1041(1987).
//
RX   PubMed=7938462; DOI=10.2307/3578897;
RA   Smeets M.F.M.A., Dahmen-Mooren E.H.M., Abdel-Wahab A.H.A.,
RA   Bartelink H., Begg A.C.;
RT   "Differential repair of radiation-induced DNA damage in cells of human
RT   squamous cell carcinoma and the effect of caffeine and cysteamine on
RT   induction and repair of DNA double-strand breaks.";
RL   Radiat. Res. 140:153-160(1994).
//
RX   PubMed=8339273;
RA   Brachman D.G., Beckett M.A., Graves D., Haraf D., Vokes E.E.,
RA   Weichselbaum R.R.;
RT   "p53 mutation does not correlate with radiosensitivity in 24 head and
RT   neck cancer cell lines.";
RL   Cancer Res. 53:3667-3669(1993).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082;
RA   Yarbrough W.G., Whigham A., Brown B., Roach M., Slebos R.J.C.;
RT   "Phosphoinositide kinase-3 status associated with presence or absence
RT   of human papillomavirus in head and neck squamous cell carcinomas.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007).
//
RX   PubMed=25888065; DOI=10.1016/j.molonc.2015.03.008; PMCID=PMC4523436;
RA   Stanam A., Love-Homan L., Joseph T.S., Espinosa-Cotton M.,
RA   Simons A.L.;
RT   "Upregulated interleukin-6 expression contributes to erlotinib
RT   resistance in head and neck squamous cell carcinoma.";
RL   Mol. Oncol. 9:1371-1383(2015).
//