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Cellosaurus MDA-1586 (CVCL_6981)

[Text version]
Cell line name MDA-1586
Synonyms MDA 1586; MDA1586
Accession CVCL_6981
Resource Identification Initiative To cite this cell line use: MDA-1586 (RRID:CVCL_6981)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273Leu (c.818G>T); ClinVar=VCV000376655; Zygosity=Unspecified (PubMed=7927946).
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO8,9
D5S81811,12
D7S8208,10
D13S31712
D16S53910
TH017,9
TPOX10,11
vWA16,17

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=7927946; DOI=10.1002/ijc.2910590316
Xu L., Davidson B.J., Murty V.V.V.S., Li R.-G., Sacks P.G., Garin-Chesa P., Schantz S.P., Chaganti R.S.K.
TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines.
Int. J. Cancer 59:383-387(1994)

PubMed=11389082
Singh B., Gogineni S.K., Sacks P.G., Shaha A.R., Shah J.P., Stoffel A., Rao P.H.
Molecular cytogenetic characterization of head and neck squamous cell carcinoma and refinement of 3q amplification.
Cancer Res. 61:4506-4513(2001)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6981
Encyclopedic resources Wikidata; Q54904555
Polymorphism and mutation databases Cosmic; 2043892
Cosmic; 2550365
IARC_TP53; 3548
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number16