ID   MDA-1586
AC   CVCL_6981
SY   MDA 1586; MDA1586
DR   cancercelllines; CVCL_6981
DR   Cosmic; 2043892
DR   Cosmic; 2550365
DR   IARC_TP53; 3548
DR   Wikidata; Q54904555
RX   PubMed=7927946;
RX   PubMed=11389082;
RX   PubMed=21868764;
RX   PubMed=28196595;
RX   PubMed=29156801;
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273Leu (c.818G>T); ClinVar=VCV000376655; Zygosity=Unspecified (PubMed=7927946).
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
ST   Source(s): PubMed=21868764
ST   Amelogenin: X,Y
ST   CSF1PO: 8,9
ST   D13S317: 12
ST   D16S539: 10
ST   D5S818: 11,12
ST   D7S820: 8,10
ST   TH01: 7,9
ST   TPOX: 10,11
ST   vWA: 16,17
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 16
//
RX   PubMed=7927946; DOI=10.1002/ijc.2910590316;
RA   Xu L., Davidson B.J., Murty V.V.V.S., Li R.-G., Sacks P.G.,
RA   Garin-Chesa P., Schantz S.P., Chaganti R.S.K.;
RT   "TP53 gene mutations and CCND1 gene amplification in head and neck
RT   squamous cell carcinoma cell lines.";
RL   Int. J. Cancer 59:383-387(1994).
//
RX   PubMed=11389082;
RA   Singh B., Gogineni S.K., Sacks P.G., Shaha A.R., Shah J.P.,
RA   Stoffel A., Rao P.H.;
RT   "Molecular cytogenetic characterization of head and neck squamous cell
RT   carcinoma and refinement of 3q amplification.";
RL   Cancer Res. 61:4506-4513(2001).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//