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Cellosaurus ACC-2 (CVCL_6872)

[Text version]
Cell line name ACC-2
Synonyms Acc-2; ACC2
Accession CVCL_6872
Resource Identification Initiative To cite this cell line use: ACC-2 (RRID:CVCL_6872)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=19557180; PubMed=20143388; PubMed=21868764; PubMed=26116706). Originally thought to originate from a 28 year old female patient with a salivary gland adenoid cystic carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00357.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Miscellaneous: Formerly the CCRID database had 3 entries describing this cell line (3111C0001CCC000272, 3131C0001000700062, 3142C0001000000048). They were one of the sources for the STR profile of this entry.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_6874 (ACC-M)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=21868764; PubMed=26116706

Markers:
AmelogeninX
CSF1PO9,10
D2S133817
D3S135815,18
D5S81811,12
D7S8208,12
D8S117912,13
D13S31712,13.3
D16S5399,10
D18S5116
D19S43313,14
D21S1127,28
FGA21
Penta D8,15
Penta E7,17
TH017
TPOX8,12
vWA16,18 (PubMed=21868764; PubMed=26116706)
17,18 (CCRID)

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
https://web.archive.org/web/20110617125837/http://www.accrf.org/pdf/accrf_update_march2009.pdf
Publications

PubMed=15495191; DOI=10.1002/gcc.20119
Raschke S., Balz V., Efferth T., Schulz W.A., Florl A.R.
Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.
Genes Chromosomes Cancer 42:58-67(2005)

PubMed=19557180; DOI=10.1371/journal.pone.0006040; PMCID=PMC2698276
Phuchareon J., Ohta Y., Woo J.M., Eisele D.W., Tetsu O.
Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2.
PLoS ONE 4:E6040-E6040(2009)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26116706; DOI=10.1096/fj.14-266718
Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

DOI=10.4103/2468-5585.200513
Liu N.-N., Zhang S.-L., Chen W.
The cross-contaminated cell lines of adenoid cystic carcinoma: a crucial concern.
Transl. Surg. 2:10-13(2017)

Cross-references
Cell line collections (Providers) CCTCC; GDC0048
Biological sample resources BioSample; SAMN03151659
Encyclopedic resources Wikidata; Q54608098
Polymorphism and mutation databases Cosmic; 932295
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number28