ID   ACC-2
AC   CVCL_6872
SY   Acc-2; ACC2
DR   BioSample; SAMN03151659
DR   CCTCC; GDC0048
DR   Cosmic; 932295
DR   Wikidata; Q54608098
RX   DOI=10.4103/2468-5585.200513;
RX   PubMed=15495191;
RX   PubMed=19557180;
RX   PubMed=20143388;
RX   PubMed=21868764;
RX   PubMed=26116706;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
WW   https://web.archive.org/web/20110617125837/http://www.accrf.org/pdf/accrf_update_march2009.pdf
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=19557180; PubMed=20143388; PubMed=21868764; PubMed=26116706). Originally thought to originate from a 28 year old female patient with a salivary gland adenoid cystic carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00357.
CC   Population: African American.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Miscellaneous: Formerly the CCRID database had 3 entries describing this cell line (3111C0001CCC000272, 3131C0001000700062, 3142C0001000000048). They were one of the sources for the STR profile of this entry.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): CCRID; PubMed=21868764; PubMed=26116706
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 12,13.3
ST   D16S539: 9,10
ST   D18S51: 16
ST   D19S433: 13,14
ST   D21S11: 27,28
ST   D2S1338: 17
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   D8S1179: 12,13
ST   FGA: 21
ST   Penta D: 8,15
ST   Penta E: 7,17
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18 (PubMed=21868764; PubMed=26116706)
ST   vWA: 17,18 (CCRID)
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 27
//
RX   DOI=10.4103/2468-5585.200513;
RA   Liu N.-N., Zhang S.-L., Chen W.;
RT   "The cross-contaminated cell lines of adenoid cystic carcinoma:
RT   a crucial concern.";
RL   Transl. Surg. 2:10-13(2017).
//
RX   PubMed=15495191; DOI=10.1002/gcc.20119;
RA   Raschke S., Balz V., Efferth T., Schulz W.A., Florl A.R.;
RT   "Homozygous deletions of CDKN2A caused by alternative mechanisms in
RT   various human cancer cell lines.";
RL   Genes Chromosomes Cancer 42:58-67(2005).
//
RX   PubMed=19557180; DOI=10.1371/journal.pone.0006040;
RA   Phuchareon J., Ohta Y., Woo J.M., Eisele D.W., Tetsu O.;
RT   "Genetic profiling reveals cross-contamination and misidentification
RT   of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS,
RT   ACCS and CAC2.";
RL   PLoS ONE 4:E6040-E6040(2009).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=26116706; DOI=10.1096/fj.14-266718;
RA   Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.;
RT   "Genetic profiling reveals an alarming rate of cross-contamination
RT   among human cell lines used in China.";
RL   FASEB J. 29:4268-4272(2015).
//