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Cellosaurus CHLA-136 (CVCL_6590)

[Text version]
Cell line name CHLA-136
Synonyms CHLA_136
Accession CVCL_6590
Resource Identification Initiative To cite this cell line use: CHLA-136 (RRID:CVCL_6590)
Comments Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
Doubling time: 53 hours (PubMed=20922763); 44 hours (COG).
Sequence variations
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=11507071).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A054 ! CHLA-122
Sex of cell Female
Age at sampling 3Y
Category Cancer cell line
STR profile Source(s): COG; PubMed=20922763

Markers:
AmelogeninX
CSF1PO10,11
D2S133823,25
D3S135815,18
D5S8189,12
D7S8208
D8S117910,13
D13S3178,11
D16S5399,12
D18S5112,18
D19S43313,14
D21S1131.2,32.2
FGA23,25
TH017
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Web pages https://www.cccells.org/PDF_Files/NB_Cell_Lines/CHLA-136%20Cell%20Line%20Data%20Sheet.pdf
http://www.pptpinvitro.org/cell_lines_panel.php
Publications

PubMed=11212268
Thompson P.M., Maris J.M., Hogarty M.D., Seeger R.C., Reynolds C.P., Brodeur G.M., White P.S.
Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma.
Cancer Res. 61:679-686(2001)

PubMed=11507071
Keshelava N., Zuo J.J., Chen P., Waidyaratne S.N., Luna M.C., Gomer C.J., Triche T.J., Reynolds C.P.
Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines.
Cancer Res. 61:6185-6193(2001)

PubMed=20922763; DOI=10.1002/pbc.22801
Kang M.H., Smith M.A., Morton C.L., Keshelava N., Houghton P.J., Reynolds C.P.
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Pediatr. Blood Cancer 56:239-249(2011)

PubMed=23202128; DOI=10.1038/ng.2493
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X.-Y., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Farooqi A.S., Dagg R.A., Choi L.M.R., Shay J.W., Reynolds C.P., Lau L.M.S.
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

Cross-references
Encyclopedic resources Wikidata; Q54812160
Polymorphism and mutation databases Cosmic; 930053
Cosmic; 1890103
IARC_TP53; 23825
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number18