ID   CHLA-136
AC   CVCL_6590
SY   CHLA_136
DR   Cosmic; 930053
DR   Cosmic; 1890103
DR   IARC_TP53; 23825
DR   Wikidata; Q54812160
RX   PubMed=11212268;
RX   PubMed=11507071;
RX   PubMed=20922763;
RX   PubMed=23202128;
RX   PubMed=24792489;
WW   Provider; CCR; -; https://www.cccells.org/PDF_Files/NB_Cell_Lines/CHLA-136%20Cell%20Line%20Data%20Sheet.pdf
CC   Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
CC   Doubling time: 53 hours (PubMed=20922763); 44 hours (COG).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=11507071).
ST   Source(s): COG; PubMed=20922763
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 8,11
ST   D16S539: 9,12
ST   D18S51: 12,18
ST   D19S433: 13,14
ST   D21S11: 31.2,32.2
ST   D2S1338: 23,25
ST   D3S1358: 15,18
ST   D5S818: 9,12
ST   D7S820: 8
ST   D8S1179: 10,13
ST   FGA: 23,25
ST   TH01: 7
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_A054 ! CHLA-122
SX   Female
AG   3Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 20
//
RX   PubMed=11212268;
RA   Thompson, Patricia M.
RA   Maris, John Matthew
RA   Hogarty, Michael D.
RA   Seeger, Robert C.
RA   Reynolds, Charles Patrick
RA   Brodeur, Garrett M.
RA   White, Peter S.
RT   "Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36
RT   or at other tumor suppressor loci in neuroblastoma.";
RL   Cancer Res. 61:679-686(2001).
//
RX   PubMed=20922763; DOI=10.1002/pbc.22801; PMCID=PMC3005554;
RA   Kang, Min H.
RA   Smith, Malcolm A.
RA   Morton, Christopher L.
RA   Keshelava, Nino
RA   Houghton, Peter J.
RA   Reynolds, Charles Patrick
RT   "National Cancer Institute pediatric preclinical testing program:
RT   model description for in vitro cytotoxicity testing.";
RL   Pediatr. Blood Cancer 56:239-249(2011).
//
RX   PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959;
RA   Sausen, Mark
RA   Leary, Rebecca J.
RA   Jones, Sian
RA   Wu, Jian
RA   Reynolds, Charles Patrick
RA   Liu, Xue-Yuan
RA   Blackford, Amanda L.
RA   Parmigiani, Giovanni
RA   Diaz, Luis Alberto Jr.
RA   Papadopoulos, Nickolas
RA   Vogelstein, Bert
RA   Kinzler, Kenneth Wayne
RA   Velculescu, Victor E.
RA   Hogarty, Michael D.
RT   "Integrated genomic analyses identify ARID1A and ARID1B alterations in
RT   the childhood cancer neuroblastoma.";
RL   Nat. Genet. 45:12-17(2013).
//
RX   PubMed=24792489; DOI=10.1007/s11060-014-1456-8;
RA   Farooqi, Ahsan S.
RA   Dagg, Rebecca A.
RA   Choi, L. Mi Rim
RA   Shay, Jerry W.
RA   Reynolds, Charles Patrick
RA   Lau, Loretta M.S.
RT   "Alternative lengthening of telomeres in neuroblastoma cell lines is
RT   associated with a lack of MYCN genomic amplification and with p53
RT   pathway aberrations.";
RL   J. Neurooncol. 119:17-26(2014).
//
RX   PubMed=11507071;
RA   Keshelava, Nino
RA   Zuo, Juan J.
RA   Chen, Ping
RA   Waidyaratne, Sitara N.
RA   Luna, Marian C.
RA   Gomer, Charles Joseph
RA   Triche, Timothy J.
RA   Reynolds, Charles Patrick
RT   "Loss of p53 function confers high-level multidrug resistance in
RT   neuroblastoma cell lines.";
RL   Cancer Res. 61:6185-6193(2001).
//