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Cellosaurus BJ1-hTERT (CVCL_6573)

[Text version]
Cell line name BJ1-hTERT
Synonyms hTERT-BJ1; HTERT-BJ1; hTERT-BJ; hTERT BJ; BJ hTERT; BJ1; BJ-1; BJ-5ta; BJ-tert; BJhTERT; BJHTERT
Accession CVCL_6573
Secondary accession CVCL_3654
Resource Identification Initiative To cite this cell line use: BJ1-hTERT (RRID:CVCL_6573)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 36 hours (PubMed=25984343).
Transfected with: HGNC; 11730; TERT.
Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
Cell type: Fibroblast of foreskin; CL=CL_1001608.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.29
Native American0.6
East Asian, North1.01
East Asian, South0
South Asian0.05
European, North73.33
European, South24.72
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3653 (BJ [Human fibroblast])
Sex of cell Male
Age at sampling <1M
Category Telomerase immortalized cell line
STR profile Source(s): ATCC; Genomics_Center_BCF_Technion; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D1S165612,16
D2S44111
D2S133816,20
D3S135814,16
D5S81812
D7S82011,12
D8S11799,11
D10S124813,17
D12S39115,23
D13S3178,9
D16S5399,13
D18S5117,19
D19S43314
D21S1129
D22S104511,15
DYS39110
FGA22,23
Penta D12,13
Penta E7,17
TH017,8
TPOX10,11
vWA16,18

Run an STR similarity search on this cell line
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/BJ-5ta_Struhl_protocol.pdf
https://www.atcc.org/en/support/technical-support/faqs/number-of-population-doublings-pdl-for-atcc-crl-4001
http://www.immanis.com/TelomeraseImmortalizedCellLineCulturingGuide.pdf
Publications

PubMed=9454332; DOI=10.1126/science.279.5349.349
Bodnar A.G., Ouellette M.M., Frolkis M., Holt S.E., Chiu C.-P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S.P., Wright W.E.
Extension of life-span by introduction of telomerase into normal human cells.
Science 279:349-352(1998)

PubMed=10655550; DOI=10.1093/hmg/9.3.403
Ouellette M.M., McDaniel L.D., Wright W.E., Shay J.W., Schultz R.A.
The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes.
Hum. Mol. Genet. 9:403-411(2000)

PubMed=24119401; DOI=10.1016/j.molcel.2013.09.009
Chen J.-Y., Lin J.-R., Tsai F.-C., Meyer T.
Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle.
Mol. Cell 52:87-100(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-4001
Cell line databases/resources CLO; CLO_0001981
cancercelllines; CVCL_6573
Cell_Model_Passport; SIDM01927
DepMap; ACH-001018
Biological sample resources BioSample; SAMN03472773
Chemistry resources ChEMBL-Cells; CHEMBL4295443
ChEMBL-Targets; CHEMBL4296512
PharmacoDB; BJhTERT_101_2019
PubChem_Cell_line; CVCL_6573
Encyclopedic resources Wikidata; Q54796970
Polymorphism and mutation databases Progenetix; CVCL_6573
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number31