Cellosaurus cell line BJ [Human fibroblast] (CVCL

Cellosaurus BJ [Human fibroblast] (CVCL_3653)

[Text version]

Cell line name

BJ [Human fibroblast]

Synonyms

FF-WT-BJ; BJ1

Accession

CVCL_3653

Resource Identification Initiative

To cite this cell line use: BJ [Human fibroblast] (RRID:CVCL_3653)

Comments

Part of: ENCODE project common cell types; tier 3.
Population: Caucasian.
Senescence: Senesces at 72 PDL. Has a long lifespan in comparison with other normal human fibroblast cell lines (ATCC=CRL-2522).
Omics: CTCF ChIP-seq epigenome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: H3K36me3 ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
Cell type: Fibroblast of foreskin; CL=CL_1001608.

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_C243 (246G1)	CVCL_C244 (246G3)	CVCL_C245 (246G4)
CVCL_C246 (246G5)	CVCL_C247 (246G6)	CVCL_DQ33 (346D1)
CVCL_DQ34 (346E1)	CVCL_DQ35 (346E2)	CVCL_DQ36 (346F1)
CVCL_DQ37 (363G1)	CVCL_VG15 (4BJ1)	CVCL_VG16 (5B1)
CVCL_VG17 (7B1)	CVCL_VG18 (7B6)	CVCL_C623 (B12-11)
CVCL_C620 (B12-2)	CVCL_C621 (B12-3)	CVCL_C622 (B12-6)
CVCL_C624 (B124-1)	CVCL_C626 (B124-10)	CVCL_C627 (B124-13)
CVCL_C625 (B124-2)	CVCL_A4YN (BGUi015-A)	CVCL_X732 (BJ epi iPS-C)
CVCL_6D12 (BJ hiPSC #11)	CVCL_6D13 (BJ hiPSC #12)	CVCL_6D14 (BJ hiPSC #5)
CVCL_6D15 (BJ hiPSC #8)	CVCL_A4QM (BJ iPSC clone 1)	CVCL_A4QN (BJ iPSC clone 2)
CVCL_A4QP (BJ iPSC clone 3)	CVCL_X737 (BJ RiPS-A)	CVCL_X738 (BJ RiPS-D)
CVCL_X739 (BJ RiPS-E)	CVCL_X740 (BJ SiPS-C)	CVCL_X741 (BJ SiPS-D)
CVCL_C922 (BJ-RiPS-1.1)	CVCL_C923 (BJ-RiPS-1.2)	CVCL_C8QN (BJ-TERT)
CVCL_C924 (BJ-RiPS-1.3)	CVCL_6573 (BJ1-hTERT)	CVCL_C921 (BJ1-iPS1)
CVCL_V235 (BJ1-iPS3)	CVCL_0G92 (BJC)	CVCL_0G93 (BJD)
CVCL_VU02 (BJFF.6)	CVCL_YR24 (CRTDi005-A)	CVCL_YR25 (CRTDi005-B)
CVCL_ZI69 (CTRL-iPSC)	CVCL_0G85 (eWT-BJ2)	CVCL_0G86 (eWT-BJ4)
CVCL_B3T9 (HHUUKDi009-A)	CVCL_QX15 (HNL1)	CVCL_RL51 (HNL2)
CVCL_RL52 (HNL4)	CVCL_RL53 (HNL5)	CVCL_RL54 (HNL6)
CVCL_RL55 (HNLp)	CVCL_C430 (IPS(Foreskin)-1)	CVCL_C431 (IPS(Foreskin)-2)
CVCL_C432 (IPS(Foreskin)-3)	CVCL_C433 (IPS(Foreskin)-4)	CVCL_YT30 (ISFi001-A)
CVCL_A8SS (ISFi002-A)	CVCL_ZZ36 (KKUi001-A)	CVCL_C1U7 (KULi003-A)
CVCL_A8MM (MILi001-A)	CVCL_B5IQ (MILi001-B)	CVCL_B5IR (MILi001-C)
CVCL_ZJ15 (MPIi005-A)	CVCL_YX99 (RCSIi001-A)	CVCL_VT49 (REGUi001-A)
CVCL_VT50 (REGUi002-A)	CVCL_RL56 (T10 [Human iPSC])	CVCL_RL57 (T11 [Human ESC])
CVCL_C1WY (UBi005-A)	CVCL_YR26 (UNIPDi004-A)	CVCL_YR27 (UNIPDi004-B)
CVCL_A5CE (UNIPDi007-A)	CVCL_D0PB (UTUi001-A)	CVCL_D0PC (UTUi001-B)
CVCL_D0PD (UTUi001-C)

Sex of cell

Male

Age at sampling

<1M

Category

Finite cell line

STR profile

Source(s): ATCC=CRL-2522; CLS=305222; PubMed=29444910

Markers:

Amelogenin	X,Y
CSF1PO	10,12
D2S1338	16,20
D3S1358	14,16
D5S818	12
D7S820	11,12
D8S1179	9,11
D13S317	8,9
D16S539	9,13
D18S51	17,19
D19S433	14
D21S11	29
FGA	22,23
Penta D	12,13
Penta E	7,17
TH01	7,8
TPOX	10,11
vWA	16,18

Web pages

https://strap.nci.nih.gov/celline_detail.php?sample_id=67
http://genome.ucsc.edu/ENCODE/protocols/cell/human/BJ_Stam_protocol.pdf

Publications

PubMed=12554677; DOI=10.1093/hmg/ddg023
Tchirkov A., Lansdorp P.M.
Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia.
Hum. Mol. Genet. 12:227-232(2003)

PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=29444910; DOI=10.1530/ERC-17-0445; PMCID=PMC5827037
Hofving T., Arvidsson Y., Almobarak B., Inge L., Pfragner R., Persson M., Stenman G., Kristiansson E., Johanson V., Nilsson O.
The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines.
Endocr. Relat. Cancer 25:367-380(2018)

Cross-references

Cell line collections (Providers)

AddexBio; P0012005/4972
ATCC; CRL-2522
CLS; 305222
Ubigene; YC-C080

Cell line databases/resources

CLO; CLO_0001980
Cell_Model_Passport; SIDM01891
Lonza; 723
SKIP; SKIP001154
TOKU-E; 672

Anatomy/cell type resources

BTO; BTO_0003807

Biological sample resources

ENCODE; ENCBS070WLP
ENCODE; ENCBS074ENC
ENCODE; ENCBS137RRI
ENCODE; ENCBS170GUW
ENCODE; ENCBS198NMJ
ENCODE; ENCBS335XLL
ENCODE; ENCBS339MSO
ENCODE; ENCBS488ZLU
ENCODE; ENCBS610AAA
ENCODE; ENCBS611AAA
ENCODE; ENCBS612AAA
ENCODE; ENCBS613AAA
ENCODE; ENCBS614AAA
ENCODE; ENCBS615AAA
ENCODE; ENCBS616AAA
ENCODE; ENCBS628EGC
ENCODE; ENCBS683XYV
ENCODE; ENCBS693PNC
ENCODE; ENCBS753AAA
ENCODE; ENCBS754AAA
ENCODE; ENCBS772THG
ENCODE; ENCBS815JWZ
ENCODE; ENCBS911DVL
ENCODE; ENCBS935PZD

CRISP screens repositories

BioGRID_ORCS_Cell_line; 1125

Chemistry resources

ChEMBL-Cells; CHEMBL3307781
ChEMBL-Targets; CHEMBL614358
PubChem_Cell_line; CVCL_3653

Encyclopedic resources

Wikidata; Q54796903

Experimental variables resources

EFO; EFO_0002779

Gene expression databases

GEO; GSM248213
GEO; GSM248214
GEO; GSM472898
GEO; GSM472924
GEO; GSM472925
GEO; GSM579886
GEO; GSM579887
GEO; GSM736518
GEO; GSM736596
GEO; GSM749677
GEO; GSM749752
GEO; GSM749770
GEO; GSM923444
GEO; GSM945178
GEO; GSM945204
GEO; GSM945207
GEO; GSM945235
GEO; GSM2988896

Entry history

Entry creation

04-Apr-2012

Last entry update

19-Dec-2024

Version number