Cellosaurus cell line CGT-6 (CVCL

Cellosaurus CGT-6 (CVCL_6566)

Cross-references
Cell line name	CGT-6
Synonyms	AtT-20ins (CGT-6); CGT6
Accession	CVCL_6566
Resource Identification Initiative	To cite this cell line use: CGT-6 (RRID:CVCL_6566)
Comments	Group: Patented cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11285. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6081; INS. Genetic integration: Method=Transfection/transduction; Gene=RGD; 3705; Slc2a2. Derived from site: In situ; Pituitary gland; UBERON=UBERON_0000007.
Disease	Mouse pituitary gland neoplasms (NCIt: C24037)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: LAF1.
Hierarchy	Parent: CVCL_1G40 (AtT-20ins)
Category	Cancer cell line
Publications	PubMed=1309953; DOI=10.1073/pnas.89.2.688; PMCID=PMC48304 Hughes S.D., Johnson J.H., Quaade C., Newgard C.B. Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells. Proc. Natl. Acad. Sci. U.S.A. 89:688-692(1992) PubMed=8325893; DOI=10.1016/S0021-9258(18)82457-7 Hughes S.D., Quaade C., Johnson J.H., Ferber S., Newgard C.B. Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism. J. Biol. Chem. 268:15205-15212(1993) PubMed=8433987; DOI=10.1073/pnas.90.4.1281; PMCID=PMC45856 Inman L.R., McAllister C.T., Chen L., Hughes S.D., Newgard C.B., Kettman J.R., Unger R.H., Johnson J.H. Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent diabetes mellitus of recent onset. Proc. Natl. Acad. Sci. U.S.A. 90:1281-1284(1993) Patent=US5427940 Newgard C.B. Engineered cells producing insulin in response to glucose. Patent number US5427940, 27-Jun-1995
Cell line collections (Providers)	ATCC; CRL-11285
Cell line databases/resources	CLO; CLO_0001768
Encyclopedic resources	Wikidata; Q54811587
Entry history
Entry creation	04-Apr-2012
Last entry update	19-Dec-2024
Version number	11