ID   CGT-6
AC   CVCL_6566
SY   AtT-20ins (CGT-6); CGT6
DR   CLO; CLO_0001768
DR   ATCC; CRL-11285
DR   Wikidata; Q54811587
RX   Patent=US5427940;
RX   PubMed=1309953;
RX   PubMed=8325893;
RX   PubMed=8433987;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11285.
CC   Transfected with: HGNC; 6081; INS.
CC   Transfected with: RGD; 3705; Slc2a2.
CC   Derived from site: In situ; Pituitary gland; UBERON=UBERON_0000007.
CC   Breed/subspecies: LAF1.
DI   NCIt; C24037; Mouse pituitary gland neoplasms
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_1G40 ! AtT-20ins
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 9
//
RX   Patent=US5427940;
RA   Newgard C.B.;
RT   "Engineered cells producing insulin in response to glucose.";
RL   Patent number US5427940, 27-Jun-1995.
//
RX   PubMed=1309953; DOI=10.1073/pnas.89.2.688;
RA   Hughes S.D., Johnson J.H., Quaade C., Newgard C.B.;
RT   "Engineering of glucose-stimulated insulin secretion and biosynthesis
RT   in non-islet cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:688-692(1992).
//
RX   PubMed=8325893; DOI=10.1016/S0021-9258(18)82457-7;
RA   Hughes S.D., Quaade C., Johnson J.H., Ferber S., Newgard C.B.;
RT   "Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers
RT   glucose-stimulated insulin secretion. Relationship to glucose
RT   metabolism.";
RL   J. Biol. Chem. 268:15205-15212(1993).
//
RX   PubMed=8433987; DOI=10.1073/pnas.90.4.1281;
RA   Inman L.R., McAllister C.T., Chen L., Hughes S.D., Newgard C.B.,
RA   Kettman J.R., Unger R.H., Johnson J.H.;
RT   "Autoantibodies to the GLUT-2 glucose transporter of beta cells in
RT   insulin-dependent diabetes mellitus of recent onset.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:1281-1284(1993).
//