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Cellosaurus A4573 (CVCL_6245)

[Text version]
Cell line name A4573
Synonyms A-4573; ES-A4573
Accession CVCL_6245
Resource Identification Initiative To cite this cell line use: A4573 (RRID:CVCL_6245)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Array-based CGH.
Omics: Protein expression by reverse-phase protein arrays.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 17Y
Category Cancer cell line
STR profile Source(s): PubMed=30879952

Markers:
AmelogeninX
CSF1PO11,13
D3S135816,17
D5S81811,12
D7S82011
D13S3178,10
D16S53912
FGA24
TH017,8
TPOX8,10
vWA18,19

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=6750238
Dickman P.S., Liotta L.A., Triche T.J.
Ewing's sarcoma. Characterization in established cultures and evidence of its histogenesis.
Lab. Invest. 47:375-382(1982)

PubMed=3004699; DOI=10.1016/0165-4608(86)90001-4
Whang-Peng J., Triche T.J., Knutsen T., Miser J.S., Kao-Shan S., Tsai S., Israel M.A.
Cytogenetic characterization of selected small round cell tumors of childhood.
Cancer Genet. Cytogenet. 21:185-208(1986)

PubMed=3390826
McKeon C., Thiele C.J., Ross R.A., Kwan M., Triche T.J., Miser J.S., Israel M.A.
Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma.
Cancer Res. 48:4307-4311(1988)

PubMed=2620246; DOI=10.3109/07357908909041371
Gulati S.C., Kwon J.-H., Atzpodien J., Triche T.J., Colvin O.M., Clarkson B.D. Sr.
In vitro chemosensitivity of two Ewing's sarcoma cell lines: implication for autologous bone marrow transplantation.
Cancer Invest. 7:411-416(1989)

DOI=10.1016/B978-0-12-333530-2.50006-X
Israel M.A., Thiele C.J.
Tumor cell lines of the peripheral nervous system.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994)

PubMed=21822310; DOI=10.1038/onc.2011.317
Mackintosh C., Ordonez J.L., Garcia-Dominguez D.J., Sevillano V., Llombart-Bosch A., Szuhai K., Scotlandi K., Alberghini M., Sciot R., Sinnaeve F., Hogendoorn P.C.W., Picci P., Knuutila S., Dirksen U., Debiec-Rychter M., Schaefer K.-L., de Alava E.
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
Oncogene 31:1287-1298(2012)

PubMed=22142829; DOI=10.1158/1078-0432.CCR-11-2056
Shukla N., Ameur N., Yilmaz I., Nafa K., Lau C.-Y., Marchetti A., Borsu L., Barr F.G., Ladanyi M.
Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.
Clin. Cancer Res. 18:748-757(2012)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29464090; DOI=10.18632/oncotarget.23815
Spurny C., Kailayangiri S., Altvater B., Jamitzky S., Hartmann W., Wardelmann E., Ranft A., Dirksen U., Amler S., Hardes J., Fluegge M., Meltzer J., Farwick N., Greune L., Rossig C.
T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G.
Oncotarget 9:6536-6549(2018)

PubMed=30879952; DOI=10.1016/j.ymthe.2019.02.014
Kailayangiri S., Altvater B., Lesch S., Balbach S.T., Gottlich C., Kuhnemundt J., Mikesch J.-H., Schelhaas S., Jamitzky S., Meltzer J., Farwick N., Greune L., Fluegge M., Kerl K., Lode H.N., Siebert N., Muller I., Walles H., Hartmann W., Rossig C.
EZH2 inhibition in Ewing sarcoma upregulates GD2 expression for targeting with gene-modified T cells.
Mol. Ther. 27:933-946(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6245
Encyclopedic resources Wikidata; Q54606924
Gene expression databases GEO; GSM510001
Polymorphism and mutation databases Cosmic; 1718428
Cosmic; 2060798
Progenetix; CVCL_6245
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number21