ID   A4573
AC   CVCL_6245
SY   A-4573; ES-A4573
DR   cancercelllines; CVCL_6245
DR   Cosmic; 1718428
DR   Cosmic; 2060798
DR   GEO; GSM510001
DR   Progenetix; CVCL_6245
DR   Wikidata; Q54606924
RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RX   PubMed=2620246;
RX   PubMed=3004699;
RX   PubMed=3390826;
RX   PubMed=6750238;
RX   PubMed=21822310;
RX   PubMed=22142829;
RX   PubMed=28196595;
RX   PubMed=29464090;
RX   PubMed=30879952;
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Omics: Array-based CGH.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): PubMed=30879952
ST   Amelogenin: X
ST   CSF1PO: 11,13
ST   D13S317: 8,10
ST   D16S539: 12
ST   D3S1358: 16,17
ST   D5S818: 11,12
ST   D7S820: 11
ST   FGA: 24
ST   TH01: 7,8
ST   TPOX: 8,10
ST   vWA: 18,19
DI   NCIt; C4817; Ewing sarcoma
DI   ORDO; Orphanet_319; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   17Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 21
//
RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RA   Israel M.A., Thiele C.J.;
RT   "Tumor cell lines of the peripheral nervous system.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994).
//
RX   PubMed=2620246; DOI=10.3109/07357908909041371;
RA   Gulati S.C., Kwon J.-H., Atzpodien J., Triche T.J., Colvin O.M.,
RA   Clarkson B.D. Sr.;
RT   "In vitro chemosensitivity of two Ewing's sarcoma cell lines:
RT   implication for autologous bone marrow transplantation.";
RL   Cancer Invest. 7:411-416(1989).
//
RX   PubMed=3004699; DOI=10.1016/0165-4608(86)90001-4;
RA   Whang-Peng J., Triche T.J., Knutsen T., Miser J.S., Kao-Shan S.,
RA   Tsai S., Israel M.A.;
RT   "Cytogenetic characterization of selected small round cell tumors of
RT   childhood.";
RL   Cancer Genet. Cytogenet. 21:185-208(1986).
//
RX   PubMed=3390826;
RA   McKeon C., Thiele C.J., Ross R.A., Kwan M., Triche T.J., Miser J.S.,
RA   Israel M.A.;
RT   "Indistinguishable patterns of protooncogene expression in two
RT   distinct but closely related tumors: Ewing's sarcoma and
RT   neuroepithelioma.";
RL   Cancer Res. 48:4307-4311(1988).
//
RX   PubMed=6750238;
RA   Dickman P.S., Liotta L.A., Triche T.J.;
RT   "Ewing's sarcoma. Characterization in established cultures and
RT   evidence of its histogenesis.";
RL   Lab. Invest. 47:375-382(1982).
//
RX   PubMed=21822310; DOI=10.1038/onc.2011.317;
RA   Mackintosh C., Ordonez J.L., Garcia-Dominguez D.J., Sevillano V.,
RA   Llombart-Bosch A., Szuhai K., Scotlandi K., Alberghini M., Sciot R.,
RA   Sinnaeve F., Hogendoorn P.C.W., Picci P., Knuutila S., Dirksen U.,
RA   Debiec-Rychter M., Schaefer K.-L., de Alava E.;
RT   "1q gain and CDT2 overexpression underlie an aggressive and highly
RT   proliferative form of Ewing sarcoma.";
RL   Oncogene 31:1287-1298(2012).
//
RX   PubMed=22142829; DOI=10.1158/1078-0432.CCR-11-2056;
RA   Shukla N., Ameur N., Yilmaz I., Nafa K., Lau C.-Y., Marchetti A.,
RA   Borsu L., Barr F.G., Ladanyi M.;
RT   "Oncogene mutation profiling of pediatric solid tumors reveals
RT   significant subsets of embryonal rhabdomyosarcoma and neuroblastoma
RT   with mutated genes in growth signaling pathways.";
RL   Clin. Cancer Res. 18:748-757(2012).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29464090; DOI=10.18632/oncotarget.23815;
RA   Spurny C., Kailayangiri S., Altvater B., Jamitzky S., Hartmann W.,
RA   Wardelmann E., Ranft A., Dirksen U., Amler S., Hardes J., Fluegge M.,
RA   Meltzer J., Farwick N., Greune L., Rossig C.;
RT   "T cell infiltration into Ewing sarcomas is associated with local
RT   expression of immune-inhibitory HLA-G.";
RL   Oncotarget 9:6536-6549(2018).
//
RX   PubMed=30879952; DOI=10.1016/j.ymthe.2019.02.014;
RA   Kailayangiri S., Altvater B., Lesch S., Balbach S.T., Gottlich C.,
RA   Kuhnemundt J., Mikesch J.-H., Schelhaas S., Jamitzky S., Meltzer J.,
RA   Farwick N., Greune L., Fluegge M., Kerl K., Lode H.N., Siebert N.,
RA   Muller I., Walles H., Hartmann W., Rossig C.;
RT   "EZH2 inhibition in Ewing sarcoma upregulates GD2 expression for
RT   targeting with gene-modified T cells.";
RL   Mol. Ther. 27:933-946(2019).
//