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Cellosaurus GT1-1 (CVCL_6236)

[Text version]
Cell line name GT1-1
Accession CVCL_6236
Secondary accession CVCL_8219
Resource Identification Initiative To cite this cell line use: GT1-1 (RRID:CVCL_6236)
Comments Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Misspelling: GTI-1; Note=Occasionally.
Derived from site: In situ; Brain, hypothalamus; UBERON=UBERON_0001898.
Cell type: GnRH neuron; CL=CL_0011111.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: (C57BL/6J x BALB/cJ) F2 transgenic with rat Gnrh1 promoter-Tg(SV40).
Hierarchy Parent: CVCL_6235 (GT1)
Children:
CVCL_6267 (ScGT1)
Category Transformed cell line
Publications

PubMed=2196069; DOI=10.1016/0896-6273(90)90028-E
Mellon P.L., Windle J.J., Goldsmith P.C., Padula C.A., Roberts J.L., Weiner R.I.
Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis.
Neuron 5:1-10(1990)

PubMed=1714837; DOI=10.1210/endo-129-3-1584
Wetsel W.C., Mellon P.L., Weiner R.I., Negro-Vilar A.
Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons.
Endocrinology 129:1584-1595(1991)

PubMed=1542682; DOI=10.1073/pnas.89.5.1852; PMCID=PMC48551
Martinez de la Escalera G., Choi A.L., Weiner R.I.
Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell line.
Proc. Natl. Acad. Sci. U.S.A. 89:1852-1855(1992)

PubMed=18406727; DOI=10.1016/1043-2760(95)00228-6
Wierman M.E., Fang Z.-Q., Kepa J.K.
GnRH gene expression in neuronal cell lines.
Trends Endocrinol. Metab. 7:60-65(1996)

Cross-references
Cell line databases/resources CCRID; 1101MOU-PUMC000009
Anatomy/cell type resources BTO; BTO_0003899
Encyclopedic resources Wikidata; Q54871826
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number19