ID   GT1-1
AC   CVCL_6236
AS   CVCL_8219
DR   BTO; BTO:0003899
DR   CCRID; 1101MOU-PUMC000009
DR   Wikidata; Q54871826
RX   PubMed=1542682;
RX   PubMed=1714837;
RX   PubMed=2196069;
RX   PubMed=18406727;
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Misspelling: GTI-1; Note=Occasionally.
CC   Derived from site: In situ; Brain, hypothalamus; UBERON=UBERON_0001898.
CC   Cell type: GnRH neuron; CL=CL_0011111.
CC   Breed/subspecies: (C57BL/6J x BALB/cJ) F2 transgenic with rat Gnrh1 promoter-Tg(SV40).
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_6235 ! GT1
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 18
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RX   PubMed=1542682; DOI=10.1073/pnas.89.5.1852; PMCID=PMC48551;
RA   Martinez de la Escalera G., Choi A.L., Weiner R.I.;
RT   "Generation and synchronization of gonadotropin-releasing hormone
RT   (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell
RT   line.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:1852-1855(1992).
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RX   PubMed=1714837; DOI=10.1210/endo-129-3-1584;
RA   Wetsel W.C., Mellon P.L., Weiner R.I., Negro-Vilar A.;
RT   "Metabolism of pro-luteinizing hormone-releasing hormone in
RT   immortalized hypothalamic neurons.";
RL   Endocrinology 129:1584-1595(1991).
//
RX   PubMed=2196069; DOI=10.1016/0896-6273(90)90028-E;
RA   Mellon P.L., Windle J.J., Goldsmith P.C., Padula C.A., Roberts J.L.,
RA   Weiner R.I.;
RT   "Immortalization of hypothalamic GnRH neurons by genetically targeted
RT   tumorigenesis.";
RL   Neuron 5:1-10(1990).
//
RX   PubMed=18406727; DOI=10.1016/1043-2760(95)00228-6;
RA   Wierman M.E., Fang Z.-Q., Kepa J.K.;
RT   "GnRH gene expression in neuronal cell lines.";
RL   Trends Endocrinol. Metab. 7:60-65(1996).
//