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Cellosaurus SK-Hep-1-NIS (CVCL_6019)

[Text version]
Cell line name SK-Hep-1-NIS
Synonyms SK-Hep1-NIS
Accession CVCL_6019
Resource Identification Initiative To cite this cell line use: SK-Hep-1-NIS (RRID:CVCL_6019)
Comments Problematic cell line: Misclassified. Parent cell line (SK-HEP-1) was originally described as originating from an adenocarcinoma of liver and thus classified as hepatocellular carcinoma. Later studies show that it most probably has arisen from endothelial cells.
Population: Caucasian.
Karyotypic information: Has lost chromosome Y (from parent cell line).
Transfected with: HGNC; 11040; SLC5A5.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Disease Liver and intrahepatic bile duct epithelial neoplasm (NCIt: C7106)
Derived from metastatic site: Ascites. Cell type=Endothelial cell.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0525 (SK-HEP-1)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
Publications

PubMed=15347726
Kang J.H., Chung J.-K., Lee Y.J., Shin J.H., Jeong J.M., Lee D.S., Lee M.C.
Establishment of a human hepatocellular carcinoma cell line highly expressing sodium iodide symporter for radionuclide gene therapy.
J. Nucl. Med. 45:1571-1576(2004)

Cross-references
Encyclopedic resources Wikidata; Q54953669
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number20