ID   SK-Hep-1-NIS
AC   CVCL_6019
SY   SK-Hep1-NIS
DR   cancercelllines; CVCL_6019
DR   Wikidata; Q54953669
RX   PubMed=15347726;
CC   Problematic cell line: Misclassified. Parent cell line (SK-HEP-1) was originally described as originating from an adenocarcinoma of liver and thus classified as hepatocellular carcinoma. Later studies show that it most probably has arisen from endothelial cells.
CC   Population: Caucasian.
CC   Karyotypic information: Has lost chromosome Y (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11040; SLC5A5.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Endothelial cell; CL=CL_0000115.
DI   NCIt; C7106; Liver and intrahepatic bile duct epithelial neoplasm
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0525 ! SK-HEP-1
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 24
//
RX   PubMed=15347726;
RA   Kang, Joo Hyun
RA   Chung, June-Key
RA   Lee, Yong Jin
RA   Shin, Jae Hoon
RA   Jeong, Jae Min
RA   Lee, Dong Soo
RA   Lee, Myung Chul
RT   "Establishment of a human hepatocellular carcinoma cell line highly
RT   expressing sodium iodide symporter for radionuclide gene therapy.";
RL   J. Nucl. Med. 45:1571-1576(2004).
//