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Cellosaurus MCF-7-FLV1000 (CVCL_5I64)

[Text version]
Cell line name MCF-7-FLV1000
Synonyms MCF-7 FLV1000; MCF-7/Flv1000; MCF7-FLV1000; MCF-7FL-1000; MCF-7-FL1000; MCF-7 FL1000; MCF7FL1000; MCF FLV1000
Accession CVCL_5I64
Resource Identification Initiative To cite this cell line use: MCF-7-FLV1000 (RRID:CVCL_5I64)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:47344; Alvocidib (Flavopiridol; HMR-1275).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=11205902
Robey R.W., Medina-Perez W.Y., Nishiyama K., Lahusen T., Miyake K., Litman T., Senderowicz A.M., Ross D.D., Bates S.E.
Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.
Clin. Cancer Res. 7:145-152(2001)

PubMed=11559526
Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W., van de Laar A., Litman T., Dean M., Bates S.E.
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5I64
Encyclopedic resources Wikidata; Q54904332
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number14