ID   MCF-7-FLV1000
AC   CVCL_5I64
SY   MCF-7 FLV1000; MCF-7/Flv1000; MCF7-FLV1000; MCF-7FL-1000; MCF-7-FL1000; MCF-7 FL1000; MCF7FL1000; MCF FLV1000
DR   cancercelllines; CVCL_5I64
DR   Wikidata; Q54904332
RX   PubMed=11205902;
RX   PubMed=11559526;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:47344; Alvocidib (Flavopiridol; HMR-1275).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 14
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RX   PubMed=11205902;
RA   Robey R.W., Medina-Perez W.Y., Nishiyama K., Lahusen T., Miyake K.,
RA   Litman T., Senderowicz A.M., Ross D.D., Bates S.E.;
RT   "Overexpression of the ATP-binding cassette half-transporter, ABCG2
RT   (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer
RT   cells.";
RL   Clin. Cancer Res. 7:145-152(2001).
//
RX   PubMed=11559526;
RA   Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W.,
RA   van de Laar A., Litman T., Dean M., Bates S.E.;
RT   "Acquired mutations in the MXR/BCRP/ABCP gene alter substrate
RT   specificity in MXR/BCRP/ABCP-overexpressing cells.";
RL   Cancer Res. 61:6635-6639(2001).
//