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Cellosaurus SVG-A (CVCL_5G13)

[Text version]
Cell line name SVG-A
Accession CVCL_5G13
Resource Identification Initiative To cite this cell line use: SVG-A (RRID:CVCL_5G13)
Comments Characteristics: Used to study trinucleotide repeat (TNR) expansion as these cells support expansiosns in culture.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSVori-).
Omics: Transcriptomics; Microarray.
Caution: In contrast to SVG p12 (Cellosaurus=CVCL_3797), this cell line is not contaminated with BK polyomavirus (PubMed=24760884).
Derived from site: In situ; Fetal brain; UBERON=UBERON_0006238.
Cell type: Astrocyte; CL=CL_0000127.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5G14 (SVG)
Children:
CVCL_C3HJ (SVG-A CHMP1A null)CVCL_VP18 (SVG-A Msh3-/-)CVCL_IM78 (SVGR2)
Sex of cell Male
Age at sampling 8-12FW
Category Transformed cell line
Publications

PubMed=11517388; DOI=10.1080/13550280152058816
Schweighardt B., Shieh J.T.C., Atwood W.J.
CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1.
J. Neurovirol. 7:155-162(2001)

PubMed=14517064; DOI=10.1016/S0042-6822(03)00389-1
Gee G.V., Manley K., Atwood W.J.
Derivation of a JC virus-resistant human glial cell line: implications for the identification of host cell factors that determine viral tropism.
Virology 314:101-109(2003)

PubMed=16945950; DOI=10.1093/nar/gkl614; PMCID=PMC1636369
Farrell B.T., Lahue R.S.
CAG*CTG repeat instability in cultured human astrocytes.
Nucleic Acids Res. 34:4495-4505(2006)

PubMed=17555786; DOI=10.1016/j.virol.2007.05.016; PMCID=PMC2062566
Manley K., Gee G.V., Simkevich C.P., Sedivy J.M., Atwood W.J.
Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression.
Virology 366:394-404(2007)

PubMed=17881653; DOI=10.1093/hmg/ddm270
Claassen D.A., Lahue R.S.
Expansions of CAG.CTG repeats in immortalized human astrocytes.
Hum. Mol. Genet. 16:3088-3096(2007)

PubMed=24760884; DOI=10.1128/JVI.00696-14; PMCID=PMC4054427
Henriksen S., Tylden G.D., Dumoulin A., Sharma B.N., Hirsch H.H., Rinaldo C.H.
The human fetal glial cell line SVG p12 contains infectious BK polyomavirus.
J. Virol. 88:7556-7568(2014)

PubMed=25288626; DOI=10.1128/JVI.01600-14; PMCID=PMC4248886
Ferenczy M.W., Major E.O.
Contamination of SVG p12 cells with BK polyomavirus occurred after deposit in the American Type Culture Collection.
J. Virol. 88:12928-12929(2014)

PubMed=28973443; DOI=10.1093/nar/gkx650; PMCID=PMC5622409
Keogh N., Chan K.Y., Li G.-M., Lahue R.S.
MutSbeta abundance and Msh3 ATP hydrolysis activity are important drivers of CTG*CAG repeat expansions.
Nucleic Acids Res. 45:10068-10078(2017)

PubMed=30044992; DOI=10.1016/j.celrep.2018.06.100; PMCID=PMC6178983
Coulter M.E., Dorobantu C.M., Lodewijk G.A., Delalande F., Cianferani S., Ganesh V.S., Smith R.S., Lim E.T.-T., Xu C.S., Pang S., Wong E.T., Lidov H.G.W., Calicchio M.L., Yang E., Gonzalez D.M., Schlaeger T.M., Mochida G.H., Hess H., Lee W.-C.A., Lehtinen M.K., Kirchhausen T.L., Haussler D., Jacobs F.M.J., Gaudin R., Walsh C.A.
The ESCRT-III protein CHMP1A mediates secretion of sonic hedgehog on a distinctive subtype of extracellular vesicles.
Cell Rep. 24:973-986.e8(2018)

Cross-references
Cell line collections (Providers) CancerTools; 153563
Ximbio; 153563
Anatomy/cell type resources BTO; BTO_0006555
Encyclopedic resources Wikidata; Q54971010
Gene expression databases GEO; GSM189708
GEO; GSM189709
GEO; GSM189710
GEO; GSM189714
GEO; GSM189715
GEO; GSM189716
Entry history
Entry creation14-Dec-2015
Last entry update10-Apr-2025
Version number16