Cellosaurus cell line V79-hCYP2E1-hSULT1A1 (CVCL

Cellosaurus V79-hCYP2E1-hSULT1A1 (CVCL_5A60)

Cross-references
Cell line name	V79-hCYP2E1-hSULT1A1
Accession	CVCL_5A60
Resource Identification Initiative	To cite this cell line use: V79-hCYP2E1-hSULT1A1 (RRID:CVCL_5A60)
Comments	Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2631; CYP2E1. Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11453; SULT1A1. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Derived from site: In situ; Lung; UBERON=UBERON_0002048. Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations	Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line). Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy	Parent: CVCL_A2GU (V79-hCYP2E1)
Sex of cell	Male
Age at sampling	Adult
Category	Spontaneously immortalized cell line
Publications	PubMed=15668106; DOI=10.1016/j.mrgentox.2004.11.005 Glatt H.-R., Schneider H., Liu Y. V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals. Mutat. Res. 580:41-52(2005) PubMed=18616954; DOI=10.1016/j.mrfmmm.2008.06.003 Liu Y.-G., Glatt H.-R. Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes. Mutat. Res. 643:64-69(2008) PubMed=19484729; DOI=10.1002/em.20503 Liu Y.-G., Glatt H.-R. Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis. Environ. Mol. Mutagen. 51:23-30(2010)
Encyclopedic resources	Wikidata; Q54992604
Entry history
Entry creation	14-Dec-2015
Last entry update	10-Sep-2024
Version number	10