ID   V79-hCYP2E1-hSULT1A1
AC   CVCL_5A60
DR   Wikidata; Q54992604
RX   PubMed=15668106;
RX   PubMed=18616954;
RX   PubMed=19484729;
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2631; CYP2E1.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11453; SULT1A1.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_A2GU ! V79-hCYP2E1
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 14-12-15; Last updated: 10-09-24; Version: 10
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RX   PubMed=15668106; DOI=10.1016/j.mrgentox.2004.11.005;
RA   Glatt H.-R., Schneider H., Liu Y.;
RT   "V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of
RT   genotoxic effects induced by carbohydrate pyrolysis products and other
RT   food-borne chemicals.";
RL   Mutat. Res. 580:41-52(2005).
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RX   PubMed=18616954; DOI=10.1016/j.mrfmmm.2008.06.003;
RA   Liu Y.-G., Glatt H.-R.;
RT   "Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line
RT   expressing two human biotransformation enzymes.";
RL   Mutat. Res. 643:64-69(2008).
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RX   PubMed=19484729; DOI=10.1002/em.20503;
RA   Liu Y.-G., Glatt H.-R.;
RT   "Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in
RT   Chinese hamster V79 cells enhance spontaneous mutagenesis.";
RL   Environ. Mol. Mutagen. 51:23-30(2010).
//