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Cellosaurus JHU-012 (CVCL_5987)

[Text version]
Cell line name JHU-012
Synonyms JHU 012; JHU-O12; JHU012; SCC012; HNSCC 012; O12; 012; Johns Hopkins University-012
Accession CVCL_5987
Resource Identification Initiative To cite this cell line use: JHU-012 (RRID:CVCL_5987)
Comments Problematic cell line: Contaminated. Shown to be a JHU-022 derivative (PubMed=21868764). Originally thought to originate from the lymph node of a metastatic floor of mouth carcinoma in a 62 year old female patient.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00403.
Population: Caucasian.
Misspelling: JHU-112; Cosmic=1530746.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5991 (JHU-022)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2720; PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO10
D5S81812,13
D7S8209,10
D13S31711
D16S53912
TH016
TPOX8
vWA14,16

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=12925955; DOI=10.1002/ijc.11341
Minhas K.M., Singh B., Jiang W.-W., Sidransky D., Califano J.A. 3rd
Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma.
Int. J. Cancer 107:46-52(2003)

PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6
Hoque M.O., Begum S., Sommer M., Lee T., Trink B., Ratovitski E., Sidransky D.
PUMA in head and neck cancer.
Cancer Lett. 199:75-81(2003)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Yarbrough W.G., Whigham A., Brown B., Roach M., Slebos R.J.C.
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

Cross-references
Cell line collections (Providers) ATCC; CRL-2720 - Discontinued
Biological sample resources BioSample; SAMN03151804
Encyclopedic resources Wikidata; Q54898668
Polymorphism and mutation databases Cosmic; 1122669
Cosmic; 1530746
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number21