ID   JHU-012
AC   CVCL_5987
SY   JHU 012; JHU-O12; JHU012; SCC012; HNSCC 012; O12; 012
DR   ATCC; CRL-2720
DR   BioSample; SAMN03151804
DR   Cosmic; 1122669
DR   Cosmic; 1530746
DR   Wikidata; Q54898668
RX   PubMed=12925955;
RX   PubMed=12963126;
RX   PubMed=17848307;
RX   PubMed=21868764;
CC   Problematic cell line: Contaminated. Shown to be a JHU-022 derivative (PubMed=21868764). Originally thought to originate from the lymph node of a metastatic floor of mouth carcinoma in a 62 year old female patient.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00403.
CC   Misspelling: JHU-112; Cosmic=1530746.
CC   Discontinued: ATCC; CRL-2720; true.
ST   Source(s): ATCC; PubMed=21868764
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 12
ST   D5S818: 12,13
ST   D7S820: 9,10
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 14,16
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_5991 ! JHU-022
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 21-03-23; Version: 19
RX   PubMed=12925955; DOI=10.1002/ijc.11341;
RA   Minhas K.M., Singh B., Jiang W.-W., Sidransky D., Califano J.A. III;
RT   "Spindle assembly checkpoint defects and chromosomal instability in
RT   head and neck squamous cell carcinoma.";
RL   Int. J. Cancer 107:46-52(2003).
RX   PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6;
RA   Hoque M.O., Begum S., Sommer M., Lee T., Trink B., Ratovitski E.,
RA   Sidransky D.;
RT   "PUMA in head and neck cancer.";
RL   Cancer Lett. 199:75-81(2003).
RX   PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082;
RA   Yarbrough W.G., Whigham A., Brown B., Roach M., Slebos R.;
RT   "Phosphoinositide kinase-3 status associated with presence or absence
RT   of human papillomavirus in head and neck squamous cell carcinomas.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007).
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).