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Cellosaurus COMMA-D (CVCL_5731)

[Text version]
Cell line name COMMA-D
Synonyms Comma-D; COMMA D; Comma 1D; Comma-1D; COMMA-1D; COMMA1D; CD
Accession CVCL_5731
Resource Identification Initiative To cite this cell line use: COMMA-D (RRID:CVCL_5731)
Comments Characteristics: Can functionally differentiate to preneoplastic and neoplastic phenotypes (PubMed=36630696).
Omics: Transcriptomics; RNAseq; Single cell.
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c.
Hierarchy Children:
CVCL_5717 (CDNR1)CVCL_5718 (CDNR2)CVCL_5719 (CDNR4)
CVCL_E1I1 (CID 9)CVCL_JZ81 (COMMA-1D/PDK1)CVCL_5732 (COMMA-D beta)
CVCL_E1II (COMMA-D clone DB-1)CVCL_U227 (COMMA-D/MME)CVCL_5G82 (COMMA-F)
CVCL_5G83 (COMMA-T)CVCL_0288 (HC11)CVCL_U228 (PS-BME-L6)
CVCL_U229 (PS-BME-L7)
Sex of cell Female
Age at sampling 1Y
Category Spontaneously immortalized cell line
Publications

PubMed=6587390; DOI=10.1073/pnas.81.12.3756; PMCID=PMC345298
Danielson K.G., Oborn C.J., Durban E.M., Butel J.S., Medina D.
Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro.
Proc. Natl. Acad. Sci. U.S.A. 81:3756-3760(1984)

PubMed=24259225; DOI=10.1007/BF02917600
Medina D., Morrison D., Oborn C.J.
Selenium retention and inhibition of cell growth in mouse mammary epithelial cell lines in vitro.
Biol. Trace Elem. Res. 8:19-35(1985)

PubMed=2423737; DOI=10.1093/jnci/76.6.1143
Medina D., Oborn C.J., Kittrell F.S., Ullrich R.L.
Properties of mouse mammary epithelial cell lines characterized by in vivo transplantation and in vitro immunocytochemical methods.
J. Natl. Cancer Inst. 76:1143-1156(1986)

PubMed=3653254; DOI=10.1016/0014-4827(87)90105-4
Medina D., Li M.-L., Oborn C.J., Bissell M.J.
Casein gene expression in mouse mammary epithelial cell lines: dependence upon extracellular matrix and cell type.
Exp. Cell Res. 172:192-203(1987)

PubMed=36630696; DOI=10.3389/fgene.2022.894597; PMCID=PMC9237515
Dave A., Nekritz E., Charytonowicz D., Beaumont M., Smith M., Beaumont K.G., Silva J., Sebra R.P.
Integration of single-cell transcriptomics with a high throughput functional screening assay to resolve cell type, growth kinetics, and stemness heterogeneity within the Comma-1D cell line.
Front. Genet. 13:894597.1-894597.20(2022)

Cross-references
Encyclopedic resources Wikidata; Q54814228
Experimental variables resources EFO; EFO_0022829
Gene expression databases GEO; GSE182589
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number16