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Cellosaurus MCF-10AT (CVCL_5555)

[Text version]
Cell line name MCF-10AT
Synonyms MCF10AT
Accession CVCL_5555
Resource Identification Initiative To cite this cell line use: MCF-10AT (RRID:CVCL_5555)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: CNV analysis.
Omics: Glycoproteome analysis by proteomics.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5554 (MCF-10A-neoT)
Children:
CVCL_5552 (MCF10DCIS.com)
Sex of cell Female
Age at sampling 36Y
Category Transformed cell line
Publications

PubMed=8546221; PMCID=PMC1861604
Dawson P.J., Wolman S.R., Tait L., Heppner G.H., Miller F.R.
MCF10AT: a model for the evolution of cancer from proliferative breast disease.
Am. J. Pathol. 148:313-319(1996)

PubMed=15375546; DOI=10.3892/ijo.25.4.961
Peng X.-J., Yun D.-R., Christov K.
Breast cancer progression in MCF10A series of cell lines is associated with alterations in retinoic acid and retinoid X receptors and with differential response to retinoids.
Int. J. Oncol. 25:961-971(2004)

PubMed=20169162; DOI=10.1371/journal.pone.0009201; PMCID=PMC2821407
Kadota M., Yang H.H., Gomez B.P., Sato M., Clifford R.J., Meerzaman D., Dunn B.K., Wakefield L.M., Lee M.P.
Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines.
PLoS ONE 5:E9201-E9201(2010)

PubMed=24262153; DOI=10.1016/j.jprot.2013.11.006; PMCID=PMC3920745
Yen T.-Y., Haste N., Timpe L.C., Litsakos-Cheung C., Yen R., Macher B.A.
Using a cell line breast cancer progression system to identify biomarker candidates.
J. Proteomics 96:173-183(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5555
IGRhCellID; MCF10AT
Encyclopedic resources Wikidata; Q54904299
Gene expression databases GEO; GSM498023
GEO; GSM498027
Polymorphism and mutation databases Progenetix; CVCL_5555
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number23