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Cellosaurus WSU-HN30 (CVCL_5525)

[Text version]
Cell line name WSU-HN30
Synonyms HN30; HN-30; Wayne State University-Head and Neck 30
Accession CVCL_5525
Resource Identification Initiative To cite this cell line use: WSU-HN30 (RRID:CVCL_5525)
Comments Part of: MD Anderson Cell Lines Project.
Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Disease Pharyngeal squamous cell carcinoma (NCIt: C102872)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5526 ! WSU-HN31
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=21868764; PubMed=25275298

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135816
D5S81812,13
D7S82010
D8S117915,17
D13S31711 (PubMed=25275298)
11,12 (PubMed=21868764)
D16S53911,12
D18S5113,16
D21S1128
FGA20,24
Penta D2.2
Penta E8,12
TH017,9
TPOX6,11
vWA15,18

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=8001221; DOI=10.1093/carcin/15.12.2683
Yeudall W.A., Crawford R.Y., Ensley J.F., Robbins K.C.
MTS1/CDK4I is altered in cell lines derived from primary and metastatic oral squamous cell carcinoma.
Carcinogenesis 15:2683-2686(1994)

PubMed=7705939; DOI=10.1002/ijc.2910610117
Cardinali M., Pietraszkiewicz H., Ensley J.F., Robbins K.C.
Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies.
Int. J. Cancer 61:98-103(1995)

PubMed=9049184; DOI=10.1002/(SICI)1098-2744(199702)18:2<89::AID-MC4>3.0.CO;2-L
Yeudall W.A., Jakus J., Ensley J.F., Robbins K.C.
Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck.
Mol. Carcinog. 18:89-96(1997)

PubMed=9389571; DOI=10.1002/(SICI)1097-0215(19971114)73:4<551::AID-IJC16>3.0.CO;2-C
Patel V., Jakus J., Harris C.M., Ensley J.F., Robbins K.C., Yeudall W.A.
Altered expression and activity of G1/S cyclins and cyclin-dependent kinases characterize squamous cell carcinomas of the head and neck.
Int. J. Cancer 73:551-555(1997)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=25275298; DOI=10.18632/oncotarget.2417
Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z.-Y., Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4
Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S., Ito Y., Myers J.N., Oridate N.
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Anatomy/cell type resources BTO; BTO:0005039
Encyclopedic resources Wikidata; Q54994487
Gene expression databases GEO; GSM1643583
Polymorphism and mutation databases Cosmic; 922084
Cosmic; 2131844
Cosmic; 2296299
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number17