Cellosaurus cell line BEL-7402 (CVCL

Cellosaurus BEL-7402 (CVCL_5492)

[Text version]

Cell line name

BEL-7402

Synonyms

Bel-7402; BEL 7402; Bel 7402; BEL7402; Bel7402

Accession

CVCL_5492

Resource Identification Initiative

To cite this cell line use: BEL-7402 (RRID:CVCL_5492)

Comments

Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=28807831). Originally thought to originate from a 53 year old male patient with a hepatocellular carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00549.
Population: African American.
Doubling time: 20 hours (PubMed=6154311); 31.2 +- 1.1 hours (PubMed=23167424).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Deep quantitative proteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Miscellaneous: Formerly the CCRID database had 2 entries describing this cell line (3131C0001000700010, 3142C0001000000035). They were the sole source for the STR profile of this entry.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.

Disease

Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0030 (HeLa)
Children:

CVCL_5493 (BEL-7402/5-FU)

CVCL_M184 (BEL-7402/5'-DFUR)

CVCL_D8ER (Ubigene BEL-7402 KLF14 KO)

Sex of cell

Female

Age at sampling

30Y6M

Category

Cancer cell line

STR profile

Source(s): CCRID

Markers:

Amelogenin	X
CSF1PO	10
D2S1338	17
D3S1358	15,18
D5S818	12
D7S820	12
D8S1179	12
D13S317	13.3
D16S539	9,10
D18S51	16
D19S433	13
D21S11	27,28
FGA	18,21
TH01	7
TPOX	12
vWA	16,18

Web pages

https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

Publications

PubMed=6154311; DOI=10.1360/ya1980-23-2-236
Chen R.-M., Zhu D.-H., Ye X.-Z., Shen D.-W., Lu R.-H.
Establishment of three human liver carcinoma cell lines and some of their biological characteristics in vitro.
Sci. Sin. 23:236-247(1980)

PubMed=6275024; DOI=10.1099/0022-1317-57-1-95
Koshy R., Maupas P., Muller R., Hofschneider P.H.
Detection of hepatitis B virus-specific DNA in the genomes of human hepatocellular carcinoma and liver cirrhosis tissues.
J. Gen. Virol. 57:95-102(1981)

DOI=10.1007/978-4-431-68349-0_4
Alexander J.J.
Human hepatoma cell lines.
(In book chapter) Neoplasms of the liver; Okuda K., Ishak K.G. (eds.); pp.47-56; Springer; Tokyo; Japan (1987)

PubMed=1849045
Fuhrer J.P., Xie H., Murphy M.J. Jr., Ye J.N., Yao Z.
Characterization of a membrane-associated glycoprotein (gp 43) on human hepatocellular carcinoma by a monoclonal antibody.
Cancer Res. 51:2158-2163(1991)

PubMed=14571772
Liu L.-X., Jiang H.-C., Liu Z.-H., Zhu A.-L., Zhou J., Zhang W.-H., Wang X.-Q., Wu M.
Gene expression profiles of hepatoma cell line BEL-7402.
Hepato-Gastroenterol. 50:1496-1501(2003)

PubMed=23167424; DOI=10.7314/APJCP.2012.13.9.4807
Gu W., Fang F.-F., Li B., Cheng B.-B., Ling C.-Q.
Characterization and resistance mechanisms of a 5-fluorouracil-resistant hepatocellular carcinoma cell line.
Asian Pac. J. Cancer Prev. 13:4807-4814(2012)

PubMed=23505090; DOI=10.1002/hep.26402
Wang K., Lim H.Y., Shi S., Lee J., Deng S.-B., Xie T., Zhu Z., Wang Y.-L., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.-C.
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Hepatology 58:706-717(2013)

PubMed=28807831; DOI=10.1016/j.jhep.2017.08.002
Rebouissou S., Zucman-Rossi J., Moreau R., Qiu Z.-X., Hui L.-J.
Note of caution: contaminations of hepatocellular cell lines.
J. Hepatol. 67:896-897(2017)

Cross-references

Cell line databases/resources

TOKU-E; 3571

Anatomy/cell type resources

BTO; BTO:0004050

Chemistry resources

ChEMBL-Cells; CHEMBL3307770
ChEMBL-Targets; CHEMBL614279
PubChem_Cell_line; CVCL_5492

Encyclopedic resources

Wikidata; Q54795968

Experimental variables resources

EFO; EFO_0022709

Gene expression databases