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Cellosaurus MCL-5 (CVCL_5332)

[Text version]
Cell line name MCL-5
Accession CVCL_5332
Resource Identification Initiative To cite this cell line use: MCL-5 (RRID:CVCL_5332)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10575.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2596; CYP1A2.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2610; CYP2A6.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2631; CYP2E1.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2637; CYP3A4.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 3401; EPHX1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06988; Escherichia coli hisD.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UU62 (AHH-1 TK+/- L3)
Sex of cell Male
Age at sampling 33Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-10575

Markers:
AmelogeninX,Y
CSF1PO10
D5S81812,13
D7S82010,11
D13S31711,13
D16S53910
TH016,9.3
TPOX8,9
vWA18,19

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Publications

PubMed=1793807; DOI=10.1021/tx00023a013
Crespi C.L., Gonzalez F.J., Steimel D.T., Turner T.R., Gelboin H.V., Penman B.W., Langenbach R.
A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing.
Chem. Res. Toxicol. 4:566-572(1991)

Patent=US5429948
Crespi C.L., Penman B.W., Davies R.L.
Human cell line stably expressing 5 cDNAS encoding procarcinogen- activating enzymes and related mutagenicity assays.
Patent number US5429948, 04-Jul-1995

PubMed=7739402; DOI=10.1093/mutage/10.1.53
Dobo K.L., Giver C.R., Eastmond D.A., Rumbos H.S., Grosovsky A.J.
Extensive loss of heterozygosity accounts for differential mutation rate on chromosome 17q in human lymphoblasts.
Mutagenesis 10:53-58(1995)

PubMed=8841477; DOI=10.1016/0027-5107(96)00133-9
Morris S.M., Manjanatha M.G., Shelton S.D., Domon O.E., McGarrity L.J., Casciano D.A.
A mutation in the p53 tumor suppressor gene of AHH-1 tk+/- human lymphoblastoid cells.
Mutat. Res. 356:129-134(1996)

Cross-references
Cell line collections (Providers) ATCC; CRL-10575 - Discontinued
Cell line databases/resources CLO; CLO_0007616
Encyclopedic resources Wikidata; Q54904516
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number17