ID   MCL-5
AC   CVCL_5332
DR   CLO; CLO_0007616
DR   ATCC; CRL-10575
DR   Wikidata; Q54904516
RX   Patent=US5429948;
RX   PubMed=1793807;
RX   PubMed=7739402;
RX   PubMed=8841477;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10575.
CC   Population: Caucasian.
CC   Transfected with: HGNC; 2596; CYP1A2.
CC   Transfected with: HGNC; 2610; CYP2A6.
CC   Transfected with: HGNC; 2631; CYP2E1.
CC   Transfected with: HGNC; 2637; CYP3A4.
CC   Transfected with: HGNC; 3401; EPHX1.
CC   Transfected with: UniProtKB; P06988; Escherichia coli hisD.
CC   Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Discontinued: ATCC; CRL-10575; true.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): ATCC=CRL-10575
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11,13
ST   D16S539: 10
ST   D5S818: 12,13
ST   D7S820: 10,11
ST   TH01: 6,9.3
ST   TPOX: 8,9
ST   vWA: 18,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_UU62 ! AHH-1 TK+/- L3
SX   Male
AG   33Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 16
//
RX   Patent=US5429948;
RA   Crespi C.L., Penman B.W., Davies R.L.;
RT   "Human cell line stably expressing 5 cDNAS encoding procarcinogen-
RT   activating enzymes and related mutagenicity assays.";
RL   Patent number US5429948, 04-Jul-1995.
//
RX   PubMed=1793807; DOI=10.1021/tx00023a013;
RA   Crespi C.L., Gonzalez F.J., Steimel D.T., Turner T.R., Gelboin H.V.,
RA   Penman B.W., Langenbach R.;
RT   "A metabolically competent human cell line expressing five cDNAs
RT   encoding procarcinogen-activating enzymes: application to mutagenicity
RT   testing.";
RL   Chem. Res. Toxicol. 4:566-572(1991).
//
RX   PubMed=7739402; DOI=10.1093/mutage/10.1.53;
RA   Dobo K.L., Giver C.R., Eastmond D.A., Rumbos H.S., Grosovsky A.J.;
RT   "Extensive loss of heterozygosity accounts for differential mutation
RT   rate on chromosome 17q in human lymphoblasts.";
RL   Mutagenesis 10:53-58(1995).
//
RX   PubMed=8841477; DOI=10.1016/0027-5107(96)00133-9;
RA   Morris S.M., Manjanatha M.G., Shelton S.D., Domon O.E.,
RA   McGarrity L.J., Casciano D.A.;
RT   "A mutation in the p53 tumor suppressor gene of AHH-1 tk+/- human
RT   lymphoblastoid cells.";
RL   Mutat. Res. 356:129-134(1996).
//