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Cellosaurus INA-6 (CVCL_5209)

[Text version]
Cell line name INA-6
Synonyms INA6
Accession CVCL_5209
Resource Identification Initiative To cite this cell line use: INA-6 (RRID:CVCL_5209)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Characteristics: Produces Ig kappa.
Characteristics: IL6 dependent.
Doubling time: ~30-50 hours (DSMZ=ACC-862).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (DepMap=ACH-000512).
  • Mutation; HGNC; 11998; TP53; Simple; p.Lys132Met (c.395A>T); ClinVar=VCV000376629; Zygosity=Heterozygous (DepMap=ACH-000512).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln331Ter (c.991C>T); ClinVar=VCV000922893; Zygosity=Heterozygous (DepMap=ACH-000512).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.46
Native American0.15
East Asian, North2.2
East Asian, South0
South Asian0
European, North63.38
European, South33.82
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0C40 (INA-6.Tu1)
Sex of cell Male
Age at sampling 80Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-862

Markers:
AmelogeninX,Y
CSF1PO10,13
D2S133816
D3S135815,16
D5S81812,13
D7S82011,12
D8S117914
D13S3178,12
D16S5399,11
D18S5112,15
D19S43314,15
D21S1129,30
FGA21,22
Penta D9
Penta E7,12
TH019,9.3
TPOX8
vWA18

Run an STR similarity search on this cell line
Web pages https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
http://www.cells-talk.com/index.php/page/copelibrary?key=INA-6
Publications

CLPUB00060
Gramatzki M., Burger R., Trautmann U., Marschalek R., Lorenz H., Hansen-Hagge T.E., Baum W., Bartram C.R., Gebhart E., Kalden J.R.
Two new interleukin-6 dependent plasma cell lines carrying a chromosomal abnormality involving the IL-6 gene locus.
Blood 84 Suppl. 1:173a-173a(1994)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

PubMed=11920233; DOI=10.1038/sj.thj.6200075
Burger R., Guenther A., Bakker F., Schmalzing M., Bernand S., Baum W., Duerr B., Hocke G.M., Steininger H., Gebhart E., Gramatzki M.
Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma.
Hematol. J. 2:42-53(2001)

PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003; PMCID=PMC2083698
Keats J.J., Fonseca R., Chesi M., Schop R., Baker A., Chng W.-J., Van Wier S., Tiedemann R., Shi C.-X., Sebag M., Braggio E., Henry T., Zhu Y.-X., Fogle H., Price-Troska T.L., Ahmann G.J., Mancini C., Brents L.A., Kumar S.K., Greipp P.R., Dispenzieri A., Bryant B., Mulligan G., Bruhn L., Barrett M.T., Valdez R., Trent J.M., Stewart A.K., Carpten J.D., Bergsagel P.L.
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
Cancer Cell 12:131-144(2007)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011; PMCID=PMC2737184
Dib A., Gabrea A., Glebov O.K., Bergsagel P.L., Kuehl W.M.
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

PubMed=19621390; DOI=10.1002/ijc.24758
Guenther A., Gordon S., Tiemann M., Burger R., Bakker F., Green J.R., Baum W., Roelofs A.J., Rogers M.J., Gramatzki M.
The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.
Int. J. Cancer 126:239-246(2010)

PubMed=22806891; DOI=10.1182/blood-2011-08-371567
Holien T., Vatsveen T.K., Hella H., Waage A., Sundan A.
Addiction to c-MYC in multiple myeloma.
Blood 120:2450-2453(2012)

CLPUB00604
Chow S.
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Sarin V., Yu K., Ferguson I.D., Gugliemini O., Nix M.A., Hann B., Sirota M., Wiita A.P.
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Cell line collections (Providers) DSMZ; ACC-862
Cell line databases/resources cancercelllines; CVCL_5209
Cell_Model_Passport; SIDM01555
DepMap; ACH-000512
DSMZCellDive; ACC-862
Anatomy/cell type resources BTO; BTO:0004745
Biological sample resources BioSample; SAMN10989605
Encyclopedic resources Wikidata; Q54897699
Experimental variables resources EFO; EFO_0005386
Polymorphism and mutation databases Cosmic; 1424216
Cosmic; 1483075
Cosmic; 2081383
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number28