Cellosaurus cell line TC-4C (CVCL

Cellosaurus TC-4C (CVCL_4Z37)

[Text version]

Cell line name

TC-4C

Accession

CVCL_4Z37

Resource Identification Initiative

To cite this cell line use: TC-4C (RRID:CVCL_4Z37)

Comments

Omics: Transcriptome analysis by RNAseq.

Sequence variations

Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:3508; EWSR1; Name(s)=EWSR1-ERG, EWS-ERG (PubMed=25010205).
Mutation; HGNC; HGNC:11355; STAG2; Unexplicit; Ex5-12del; Zygosity=Hemizygous (PubMed=25010205).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu194Arg (c.581T>G); ClinVar=VCV000376633; Zygosity=Unspecified (PubMed=25010205).

Disease

Ewing sarcoma/peripheral primitive neuroectodermal tumor (NCIt: C27291)
Bone sarcoma (ORDO: Orphanet_223727)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Category

Cancer cell line

STR profile

Source(s): PubMed=25010205

Markers:

Amelogenin	X,Y
CSF1PO	11
D2S1338	19,26
D3S1358	16
D5S818	10
D7S820	11
D8S1179	12
D13S317	13
D16S539	9,11
D18S51	12,17
D19S433	14,16.2
D21S11	29
FGA	20,22
TH01	9.3
TPOX	8
vWA	15,18

Publications

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Brohl A.S., Solomon D.A., Chang W., Wang J.-J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H.-L., Wen X.-Y., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M.M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_4Z37

Encyclopedic resources

Wikidata; Q54971814

Polymorphism and mutation databases

Cosmic; 2228245

Entry history

Entry creation

14-Dec-2015

Last entry update

19-Dec-2024

Version number