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Cellosaurus MOLT-4/ADR (CVCL_4Y72)

[Text version]
Cell line name MOLT-4/ADR
Synonyms Molt-4/ADR; MAR
Accession CVCL_4Y72
Resource Identification Initiative To cite this cell line use: MOLT-4/ADR (RRID:CVCL_4Y72)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0013 (MOLT-4)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=25457413; DOI=10.1016/j.imbio.2014.10.015
Wang L.-Y., Chen B.-Y., Lin M.-H., Cao Y.-Q., Chen Y.-Y., Chen X.-J., Liu T.-B., Hu J.-D.
Decreased expression of nucleophosmin/B23 increases drug sensitivity of adriamycin-resistant Molt-4 leukemia cells through mdr-1 regulation and Akt/mTOR signaling.
Immunobiology 220:331-340(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4Y72
Encyclopedic resources Wikidata; Q54906368
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number15