| Cell line name |
MOLT-4/ADR |
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| Synonyms |
Molt-4/ADR; MAR |
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| Accession |
CVCL_4Y72 |
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| Resource Identification Initiative |
To cite this cell line use: MOLT-4/ADR (RRID:CVCL_4Y72) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0013 (MOLT-4) |
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| Sex of cell |
Male |
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| Age at sampling |
19Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=25457413; DOI=10.1016/j.imbio.2014.10.015
Wang L.-Y., Chen B.-Y., Lin M.-H., Cao Y.-Q., Chen Y.-Y., Chen X.-J., Liu T.-B., Hu J.-D.
Decreased expression of nucleophosmin/B23 increases drug sensitivity of adriamycin-resistant Molt-4 leukemia cells through mdr-1 regulation and Akt/mTOR signaling.
Immunobiology 220:331-340(2015) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_4Y72
|
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| Encyclopedic resources |
Wikidata; Q54906368
|
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| Entry history |
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| Entry creation | 14-Dec-2015 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 15 |
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