ID   MOLT-4/ADR
AC   CVCL_4Y72
SY   Molt-4/ADR; MAR
DR   cancercelllines; CVCL_4Y72
DR   Wikidata; Q54906368
RX   PubMed=25457413;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0013 ! MOLT-4
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 15
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RX   PubMed=25457413; DOI=10.1016/j.imbio.2014.10.015;
RA   Wang L.-Y., Chen B.-Y., Lin M.-H., Cao Y.-Q., Chen Y.-Y., Chen X.-J.,
RA   Liu T.-B., Hu J.-D.;
RT   "Decreased expression of nucleophosmin/B23 increases drug sensitivity
RT   of adriamycin-resistant Molt-4 leukemia cells through mdr-1 regulation
RT   and Akt/mTOR signaling.";
RL   Immunobiology 220:331-340(2015).
//