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Cellosaurus 48BR (CVCL_4T39)

[Text version]
Cell line name 48BR
Synonyms 48 BRighton
Accession CVCL_4T39
Resource Identification Initiative To cite this cell line use: 48BR (RRID:CVCL_4T39)
Comments Doubling time: 45.5 hours (PubMed=6459055).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WX37 (48BRhTERT)
Sex of cell Female
Age at sampling 48Y
Category Finite cell line
Publications

PubMed=6459055; DOI=10.1111/j.1469-1809.1981.tb00320.x
Delhanty J.D.A., Parrington J.M., Casey G., Attwood J., West L., Kirk D., Corney G.
Growth, DNA repair, sister chromatid exchange and chromosome studies in fibroblasts from Huntington's disease patients.
Ann. Hum. Genet. 45:181-198(1981)

DOI=10.1007/978-1-4757-1117-2_12
Arlett C.F., Harcourt S.A.
The mutagen sensitivity response of cells from individuals heterozygous for DNA repair deficiency genes.
(In book chapter) The use of human cells for the evaluation of risk from physical and chemical agents; Castellani A. (eds.); pp.155-167; Springer; Boston; USA (1983)

PubMed=6408472; DOI=10.1016/0027-5107(83)90177-X
Teo I.A., Arlett C.F., Harcourt S.A., Priestley A., Broughton B.C.
Multiple hypersensitivity to mutagens in a cell strain (46BR) derived from a patient with immuno-deficiencies.
Mutat. Res. 107:371-386(1983)

PubMed=6600729; DOI=10.1080/09553008314550171
Arlett C.F., Priestley A.
Defective recovery from potentially lethal damage in some human fibroblast cell strains.
Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 43:157-167(1983)

PubMed=2458832
Lehmann A.R., Arlett C.F., Broughton B.C., Harcourt S.A., Steingrimsdottir H., Stefanini M., Taylor A.M.R., Natarajan A.T., Green S., King M.D., MacKie R.M., Stephenson J.B.P., Tolmie J.L.
Trichothiodystrophy, a human DNA repair disorder with heterogeneity in the cellular response to ultraviolet light.
Cancer Res. 48:6090-6096(1988)

PubMed=2903889; DOI=10.1080/09553008814552321
Arlett C.F., Green M.H.L., Priestley A., Harcourt S.A., Mayne L.V.
Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes.
Int. J. Radiat. Biol. 54:911-928(1988)

PubMed=2973075; DOI=10.2307/3577479
Fertil B., Deschavanne P.J., Debieu D., Malaise E.-P.
Correlation between PLD repair capacity and the survival curve of human fibroblasts in exponential growth phase: analysis in terms of several parameters.
Radiat. Res. 116:74-88(1988)

PubMed=3347209; DOI=10.1016/0167-8817(88)90048-x
Squires S., Johnson R.T.
Kinetic analysis of UV-induced incision discriminates between fibroblasts from different xeroderma pigmentosum complementation groups, XPA heterozygotes and normal individuals.
Mutat. Res. 193:181-192(1988)

PubMed=15574327; DOI=10.1016/j.molcel.2004.10.029
Riballo E., Kuhne M., Rief N., Doherty A., Smith G.C.M., Recio M.-J., Reis C., Dahm K., Fricke A., Krempler A., Parker A.R., Jackson S.P., Gennery A.R., Jeggo P.A., Lobrich M.
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Mol. Cell 16:715-724(2004)

PubMed=16874298; DOI=10.1038/sj.emboj.7601255; PMCID=PMC1553186
Goodarzi A.A., Yu Y.-P., Riballo E., Douglas P., Walker S.A., Ye R.-Q., Harer C., Marchetti C., Morrice N., Jeggo P.A., Lees-Miller S.P.
DNA-PK autophosphorylation facilitates Artemis endonuclease activity.
EMBO J. 25:3880-3889(2006)

PubMed=19179371; DOI=10.1093/nar/gkp023; PMCID=PMC2651789
Limsirichaikul S., Niimi A., Fawcett H., Lehmann A.R., Yamashita S., Ogi T.
A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of ethynyl deoxyuridine (EdU).
Nucleic Acids Res. 37:e31.1-e31.10(2009)

PubMed=22466610; DOI=10.1038/ng.2229
Nakazawa Y., Sasaki K., Mitsutake N., Matsuse M., Shimada M., Nardo T., Takahashi Y., Ohyama K., Ito K., Mishima H., Nomura M., Kinoshita A., Ono S., Takenaka K., Masuyama R., Kudo T., Slor H., Utani A., Tateishi S., Yamashita S., Stefanini M., Lehmann A.R., Yoshiura K.-i., Ogi T.
Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair.
Nat. Genet. 44:586-592(2012)

Cross-references
Encyclopedic resources Wikidata; Q54603308
Experimental variables resources EFO; EFO_0022569
Entry history
Entry creation22-Sep-2015
Last entry update10-Sep-2024
Version number11