ID   48BR
AC   CVCL_4T39
SY   48 BRighton
DR   EFO; EFO_0022569
DR   Wikidata; Q54603308
RX   DOI=10.1007/978-1-4757-1117-2_12;
RX   PubMed=2458832;
RX   PubMed=2903889;
RX   PubMed=2973075;
RX   PubMed=3347209;
RX   PubMed=6408472;
RX   PubMed=6459055;
RX   PubMed=6600729;
RX   PubMed=15574327;
RX   PubMed=16874298;
RX   PubMed=19179371;
RX   PubMed=22466610;
CC   Doubling time: 45.5 hours (PubMed=6459055).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   48Y
CA   Finite cell line
DT   Created: 22-09-15; Last updated: 10-09-24; Version: 11
//
RX   DOI=10.1007/978-1-4757-1117-2_12;
RA   Arlett C.F., Harcourt S.A.;
RT   "The mutagen sensitivity response of cells from individuals
RT   heterozygous for DNA repair deficiency genes.";
RL   (In book chapter) The use of human cells for the evaluation of risk from physical and chemical agents; Castellani A. (eds.); pp.155-167; Springer; Boston; USA (1983).
//
RX   PubMed=2458832;
RA   Lehmann A.R., Arlett C.F., Broughton B.C., Harcourt S.A.,
RA   Steingrimsdottir H., Stefanini M., Taylor A.M.R., Natarajan A.T.,
RA   Green S., King M.D., MacKie R.M., Stephenson J.B.P., Tolmie J.L.;
RT   "Trichothiodystrophy, a human DNA repair disorder with heterogeneity
RT   in the cellular response to ultraviolet light.";
RL   Cancer Res. 48:6090-6096(1988).
//
RX   PubMed=2903889; DOI=10.1080/09553008814552321;
RA   Arlett C.F., Green M.H.L., Priestley A., Harcourt S.A., Mayne L.V.;
RT   "Comparative human cellular radiosensitivity: I. The effect of SV40
RT   transformation and immortalisation on the gamma-irradiation survival
RT   of skin derived fibroblasts from normal individuals and from
RT   ataxia-telangiectasia patients and heterozygotes.";
RL   Int. J. Radiat. Biol. 54:911-928(1988).
//
RX   PubMed=2973075; DOI=10.2307/3577479;
RA   Fertil B., Deschavanne P.J., Debieu D., Malaise E.-P.;
RT   "Correlation between PLD repair capacity and the survival curve of
RT   human fibroblasts in exponential growth phase: analysis in terms of
RT   several parameters.";
RL   Radiat. Res. 116:74-88(1988).
//
RX   PubMed=3347209; DOI=10.1016/0167-8817(88)90048-x;
RA   Squires S., Johnson R.T.;
RT   "Kinetic analysis of UV-induced incision discriminates between
RT   fibroblasts from different xeroderma pigmentosum complementation
RT   groups, XPA heterozygotes and normal individuals.";
RL   Mutat. Res. 193:181-192(1988).
//
RX   PubMed=6408472; DOI=10.1016/0027-5107(83)90177-X;
RA   Teo I.A., Arlett C.F., Harcourt S.A., Priestley A., Broughton B.C.;
RT   "Multiple hypersensitivity to mutagens in a cell strain (46BR) derived
RT   from a patient with immuno-deficiencies.";
RL   Mutat. Res. 107:371-386(1983).
//
RX   PubMed=6459055; DOI=10.1111/j.1469-1809.1981.tb00320.x;
RA   Delhanty J.D.A., Parrington J.M., Casey G., Attwood J., West L.,
RA   Kirk D., Corney G.;
RT   "Growth, DNA repair, sister chromatid exchange and chromosome studies
RT   in fibroblasts from Huntington's disease patients.";
RL   Ann. Hum. Genet. 45:181-198(1981).
//
RX   PubMed=6600729; DOI=10.1080/09553008314550171;
RA   Arlett C.F., Priestley A.;
RT   "Defective recovery from potentially lethal damage in some human
RT   fibroblast cell strains.";
RL   Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 43:157-167(1983).
//
RX   PubMed=15574327; DOI=10.1016/j.molcel.2004.10.029;
RA   Riballo E., Kuhne M., Rief N., Doherty A., Smith G.C.M., Recio M.-J.,
RA   Reis C., Dahm K., Fricke A., Krempler A., Parker A.R., Jackson S.P.,
RA   Gennery A.R., Jeggo P.A., Lobrich M.;
RT   "A pathway of double-strand break rejoining dependent upon ATM,
RT   Artemis, and proteins locating to gamma-H2AX foci.";
RL   Mol. Cell 16:715-724(2004).
//
RX   PubMed=16874298; DOI=10.1038/sj.emboj.7601255; PMCID=PMC1553186;
RA   Goodarzi A.A., Yu Y.-P., Riballo E., Douglas P., Walker S.A., Ye R.-Q.,
RA   Harer C., Marchetti C., Morrice N., Jeggo P.A., Lees-Miller S.P.;
RT   "DNA-PK autophosphorylation facilitates Artemis endonuclease
RT   activity.";
RL   EMBO J. 25:3880-3889(2006).
//
RX   PubMed=19179371; DOI=10.1093/nar/gkp023; PMCID=PMC2651789;
RA   Limsirichaikul S., Niimi A., Fawcett H., Lehmann A.R., Yamashita S.,
RA   Ogi T.;
RT   "A rapid non-radioactive technique for measurement of repair synthesis
RT   in primary human fibroblasts by incorporation of ethynyl deoxyuridine
RT   (EdU).";
RL   Nucleic Acids Res. 37:e31.1-e31.10(2009).
//
RX   PubMed=22466610; DOI=10.1038/ng.2229;
RA   Nakazawa Y., Sasaki K., Mitsutake N., Matsuse M., Shimada M.,
RA   Nardo T., Takahashi Y., Ohyama K., Ito K., Mishima H., Nomura M.,
RA   Kinoshita A., Ono S., Takenaka K., Masuyama R., Kudo T., Slor H.,
RA   Utani A., Tateishi S., Yamashita S., Stefanini M., Lehmann A.R.,
RA   Yoshiura K.-i., Ogi T.;
RT   "Mutations in UVSSA cause UV-sensitive syndrome and impair RNA
RT   polymerase IIo processing in transcription-coupled nucleotide-excision
RT   repair.";
RL   Nat. Genet. 44:586-592(2012).
//