Cellosaurus cell line MP46 (CVCL

Cellosaurus MP46 (CVCL_4D13)

[Text version]

Cell line name

MP46

Accession

CVCL_4D13

Resource Identification Initiative

To cite this cell line use: MP46 (RRID:CVCL_4D13)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: Established from a patient-derived xenograft.
Doubling time: 110 hours (PubMed=24994677).
Omics: SNP array analysis.
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.

Sequence variations

Mutation; HGNC; HGNC:4390; GNAQ; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000375955; Zygosity=Unspecified (PubMed=24994677).

Disease

Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

69Y

Category

Cancer cell line

STR profile

Source(s): ATCC=CRL-3298; DepMap=ACH-002011; PubMed=24994677

Markers:

Amelogenin	X
CSF1PO	11
D3S1358	18
D5S818	12
D7S820	11
D8S1179	11,12,15
D13S317	10,12
D16S539	12
D18S51	13
D21S11	30,31
FGA	22,22.2,24
Penta D	9,12
Penta E	12
TH01	9
TPOX	11
vWA	16,17

Publications

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590
Amirouchene-Angelozzi N., Nemati F., Gentien D., Nicolas A., Dumont A., Carita G., Camonis J., Desjardins L., Cassoux N., Piperno-Neumann S., Mariani P., Sastre-Garau X., Decaudin D., Roman-Roman S.
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014)

Cross-references

Cell line collections (Providers)

ATCC; CRL-3298

Cell line databases/resources

cancercelllines; CVCL_4D13
Cell_Model_Passport; SIDM01789
DepMap; ACH-002011

Encyclopedic resources

Wikidata; Q54906430

Entry history

Entry creation

22-Sep-2015

Last entry update

19-Dec-2024

Version number