ID   MP46
AC   CVCL_4D13
DR   ATCC; CRL-3298
DR   cancercelllines; CVCL_4D13
DR   Cell_Model_Passport; SIDM01789
DR   DepMap; ACH-002011
DR   PRIDE; PXD051055
DR   Wikidata; Q54906430
RX   PubMed=24994677;
RX   PubMed=39042403;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Characteristics: Established from a patient-derived xenograft (PubMed=24994677).
CC   Doubling time: 110 hours (PubMed=24994677).
CC   Sequence variation: Mutation; HGNC; HGNC:4390; GNAQ; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000375955; Zygosity=Unspecified (PubMed=24994677).
CC   Omics: Proteomics.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
ST   Source(s): ATCC=CRL-3298; DepMap=ACH-002011; PubMed=24994677
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 10,12
ST   D16S539: 12
ST   D18S51: 13
ST   D21S11: 30,31
ST   D3S1358: 18
ST   D5S818: 12
ST   D7S820: 11
ST   D8S1179: 11,12,15
ST   FGA: 22,22.2,24
ST   Penta D: 9,12
ST   Penta E: 12
ST   TH01: 9
ST   TPOX: 11
ST   vWA: 16,17
DI   NCIt; C7712; Uveal melanoma
DI   ORDO; Orphanet_39044; Uveal melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 22-09-15; Last updated: 14-08-25; Version: 14
//
RX   PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590;
RA   Amirouchene-Angelozzi, Nabil
RA   Nemati, Fariba
RA   Gentien, David
RA   Nicolas, Andre
RA   Dumont, Amaury
RA   Carita, Guillaume
RA   Camonis, Jacques
RA   Desjardins, Laurence
RA   Cassoux, Nathalie
RA   Piperno-Neumann, Sophie
RA   Mariani, Pascale
RA   Sastre-Garau, Xavier
RA   Decaudin, Didier
RA   Roman-Roman, Sergio
RT   "Establishment of novel cell lines recapitulating the genetic
RT   landscape of uveal melanoma and preclinical validation of mTOR as a
RT   therapeutic target.";
RL   Mol. Oncol. 8:1508-1520(2014).
//
RX   PubMed=39042403; DOI=10.1167/iovs.65.8.37; PMCID=PMC11268447;
RA   Gelmi, Maria Chiara
RA   de Ru, Arnoud H.
RA   van Veelen, Peter A.
RA   Tjokrodirijo, Rayman T.N.
RA   Stern, Marc-Henri
RA   Houy, Alexandre
RA   Verdijk, Robert M.
RA   Vu, T.H. Khanh
RA   Ksander, Bruce R.
RA   Vaarwater, Jolanda
RA   Kilic, Emine
RA   Brosens, Erwin
RA   Jager, Martine Johanna
RT   "Protein and mRNA expression in uveal melanoma cell lines are related
RT   to GNA and BAP1 mutation status.";
RL   Invest. Ophthalmol. Vis. Sci. 65:37-37(2024).
//