ID   MP46
AC   CVCL_4D13
DR   ATCC; CRL-3298
DR   cancercelllines; CVCL_4D13
DR   Cell_Model_Passport; SIDM01789
DR   DepMap; ACH-002011
DR   Wikidata; Q54906430
RX   PubMed=24994677;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Characteristics: Established from a patient-derived xenograft.
CC   Doubling time: 110 hours (PubMed=24994677).
CC   Sequence variation: Mutation; HGNC; 4390; GNAQ; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000375955; Zygosity=Unspecified (PubMed=24994677).
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
ST   Source(s): ATCC=CRL-3298; DepMap=ACH-002011; PubMed=24994677
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 10,12
ST   D16S539: 12
ST   D18S51: 13
ST   D21S11: 30,31
ST   D3S1358: 18
ST   D5S818: 12
ST   D7S820: 11
ST   D8S1179: 11,12,15
ST   FGA: 22,22.2,24
ST   Penta D: 9,12
ST   Penta E: 12
ST   TH01: 9
ST   TPOX: 11
ST   vWA: 16,17
DI   NCIt; C7712; Uveal melanoma
DI   ORDO; Orphanet_39044; Uveal melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 22-09-15; Last updated: 02-05-24; Version: 11
//
RX   PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004;
RA   Amirouchene-Angelozzi N., Nemati F., Gentien D., Nicolas A.,
RA   Dumont A., Carita G., Camonis J., Desjardins L., Cassoux N.,
RA   Piperno-Neumann S., Mariani P., Sastre X., Decaudin D.,
RA   Roman-Roman S.;
RT   "Establishment of novel cell lines recapitulating the genetic
RT   landscape of uveal melanoma and preclinical validation of mTOR as a
RT   therapeutic target.";
RL   Mol. Oncol. 8:1508-1520(2014).
//