Cellosaurus cell line LIM2550 (CVCL

Cellosaurus LIM2550 (CVCL_4442)

[Text version]

Cell line name

LIM2550

Synonyms

LIM 2550; LIM-2550

Accession

CVCL_4442

Resource Identification Initiative

To cite this cell line use: LIM2550 (RRID:CVCL_4442)

Comments

From: Ludwig Institute for Cancer Research, Melbourne Branch; Melbourne; Australia.
Microsatellite instability: Instable (MSI) (PubMed=19378335; PubMed=25926053).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.

Sequence variations

Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000177881; Zygosity=Heterozygous (PubMed=19378335).
Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (PubMed=19378335).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Asp (c.734G>A); ClinVar=VCV000012355; Zygosity=Unspecified (PubMed=19378335).

Disease

Colon carcinoma (NCIt: C4910)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Category

Cancer cell line

STR profile

Source(s): CBA=CBA-0169; PubMed=25926053

Markers:

Amelogenin	X,Y
CSF1PO	12
D2S1338	17,23
D3S1358	15,18
D5S818	12,13
D7S820	9,10
D8S1179	14,15
D13S317	12,15
D16S539	9,14
D18S51	13,14
D19S433	11,14
D21S11	29,31.2
FGA	21,22
TH01	8,9
TPOX	8
vWA	14,19

Publications

PubMed=19378335; DOI=10.1002/ijc.24289
Zhang H.-H., Walker F.E., Kiflemariam S., Whitehead R.H., Williams D., Phillips W.A., Mikeska T., Dobrovic A., Burgess A.W.
Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
Int. J. Cancer 125:297-307(2009)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cross-references

Cell line collections (Providers)

CBA; CBA-0169
ECACC; 12070504

Cell line databases/resources

cancercelllines; CVCL_4442
ColonAtlas; LIM2550

Biological sample resources

BioSample; SAMN07624417

Encyclopedic resources

Wikidata; Q54902540

Gene expression databases

GEO; GSM1448168

Polymorphism and mutation databases

Cosmic; 1238058
Cosmic; 1486140
Cosmic; 1805262

Entry history

Entry creation

04-Apr-2012

Last entry update

19-Dec-2024

Version number