Cellosaurus HBL-100 (CVCL_4362)
Cell line name | HBL-100 | ||||||||||||||||||||||||||||||||||||
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Synonyms | HBL 100; HBL100 | ||||||||||||||||||||||||||||||||||||
Accession | CVCL_4362 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: HBL-100 (RRID:CVCL_4362) | ||||||||||||||||||||||||||||||||||||
Comments | Problematic cell line: Misidentified. Presence of a Y chromosome in cell line that was thought to be of female origin (PubMed=16643607; PubMed=20143388). Originally thought to originate from a casein-producing breast cell line from a 27 year old Caucasian woman. In addition contains SV40 genomic sequence while the cell line was deemed to be spontaneously immortalized. Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: JWGray breast cancer cell line panel. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00207. Virology: Contains 2 copies of the SV40 genome, one complete the other incomplete tandemly integrated in the cell line genome. Doubling time: 28 hours (Note=At 10th passage) (PubMed=6891286); 1.5 days (PubMed=9671407); ~40 hours (CLS=300178); 30.21 hours (JWGray panel). Karyotypic information: Near triploid with the modal number of 67 chromosomes (ATCC=HTB-124). Microsatellite instability: Stable (MSS) (PubMed=12661003). Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Omics: Array-based CGH. Omics: Deep exome analysis. Omics: DNA methylation analysis. Omics: Protein expression by reverse-phase protein arrays. Omics: SNP array analysis. Omics: Transcriptome analysis by microarray. Omics: Transcriptome analysis by RNAseq. | ||||||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=26589293
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Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||||||
Hierarchy | Children:
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Sex of cell | Male | ||||||||||||||||||||||||||||||||||||
Age at sampling | Age unspecified | ||||||||||||||||||||||||||||||||||||
Category | Transformed cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): ATCC=HTB-124; CCRID; CLS=300178; PubMed=11416159; PubMed=25877200; PubMed=28889351 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-297.html https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx https://www.synapse.org/#!Synapse:syn2346643/wiki/62255 | ||||||||||||||||||||||||||||||||||||
Publications | CLPUB00368 PubMed=6891286; DOI=10.1007/BF00204786 PubMed=6500159; DOI=10.1159/000163283 PubMed=2995096; DOI=10.1016/0014-4827(85)90238-1 PubMed=3109929; DOI=10.1016/0014-4827(87)90318-1 PubMed=2840847 PubMed=2547730; DOI=10.1002/ijc.2910440230 DOI=10.1016/B978-0-12-333530-2.50009-5 PubMed=9671407; DOI=10.1038/sj.onc.1201814 PubMed=10969801 PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459 PubMed=12661003; DOI=10.1002/gcc.10196 PubMed=16643607; DOI=10.1111/j.1749-0774.2005.00007.x PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521 DOI=10.25904/1912/1434 PubMed=20143388; DOI=10.1002/ijc.25242 PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310 PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=25877200; DOI=10.1038/nature14397 PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878 PubMed=28889351; DOI=10.1007/s10549-017-4496-x | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections (Providers) | ATCC; HTB-124 - Discontinued
CCTCC; GDC0195 CLS; 300178 RCB; RCB0460 - Discontinued Ubigene; YC-C013 | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLO; CLO_0003626
CLDB; cl1571 CCRID; 1101HUM-PUMC000374 CCRID; 3101HUMGNHu10 DepMap; ACH-002321 LINCS_HMS; 51117 TOKU-E; 3589 | ||||||||||||||||||||||||||||||||||||
Anatomy/cell type resources | BTO; BTO:0004734 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03152011
BioSample; SAMN03471101 BioSample; SAMN03472914 | ||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307713
ChEMBL-Targets; CHEMBL614811 PharmacoDB; HBL100_443_2019 PubChem_Cell_line; CVCL_4362 | ||||||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q54881428 | ||||||||||||||||||||||||||||||||||||
Experimental variables resources | EFO; EFO_0001167 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-2706
ArrayExpress; E-TABM-157 GEO; GSM1053697 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 687471
Cosmic; 877447 Cosmic; 934533 Cosmic; 979722 Cosmic; 991323 Cosmic; 1010933 Cosmic; 1136364 Cosmic; 1176632 Cosmic; 1434949 Cosmic; 1524348 Cosmic; 1609469 IARC_TP53; 21063 | ||||||||||||||||||||||||||||||||||||
Sequence databases | EGA; EGAS00001000610 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry update | 10-Sep-2024 | ||||||||||||||||||||||||||||||||||||
Version number | 37 |