Cellosaurus cell line 23 ScCr (CVCL

Cross-references
Cell line name	23 ScCr
Synonyms	10ScNCr/23
Accession	CVCL_3634
Resource Identification Initiative	To cite this cell line use: 23 ScCr (RRID:CVCL_3634)
Comments	Characteristics: Not responsive to LPS signaling. Maintains responsiveness to bacterial pathogen signaling through alternative TLRs, such as TLR2 (for example S. aureus LTA stimulation) (PubMed=12183533). Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. Cell type: Macrophage; CL=CL_0000235.
Sequence variations	Gene deletion; MGI; MGI:96824; Tlr4; Zygosity=Homozygous (PubMed=12183533).
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C57BL/10ScN.
Sex of cell	Sex unspecified
Age at sampling	6M
Category	Spontaneously immortalized cell line
Publications	PubMed=12183533; DOI=10.1128/IAI.70.9.4892-4896.2002; PMCID=PMC128243 Lorenz E., Patel D.D., Hartung T., Schwartz D.A. Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. Infect. Immun. 70:4892-4896(2002)
Cell line collections (Providers)	ATCC; CRL-2751
Cell line databases/resources	CLO; CLO_0001201
Encyclopedic resources	Wikidata; Q54583387
Entry history
Entry creation	04-Apr-2012
Last entry update	19-Dec-2024
Version number	12