ID   23 ScCr
AC   CVCL_3634
SY   10ScNCr/23
DR   CLO; CLO_0001201
DR   ATCC; CRL-2751
DR   Wikidata; Q54583387
RX   PubMed=12183533;
CC   Characteristics: Not responsive to LPS signaling. Maintains responsiveness to bacterial pathogen signaling through alternative TLRs, such as TLR2 (for example S. aureus LTA stimulation) (PubMed=12183533).
CC   Sequence variation: Gene deletion; MGI; MGI:96824; Tlr4; Zygosity=Homozygous (PubMed=12183533).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: Macrophage; CL=CL_0000235.
CC   Breed/subspecies: C57BL/10ScN.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   6M
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 12
//
RX   PubMed=12183533; DOI=10.1128/IAI.70.9.4892-4896.2002; PMCID=PMC128243;
RA   Lorenz E., Patel D.D., Hartung T., Schwartz D.A.;
RT   "Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as
RT   an in vitro assay system to show TLR4-independent signaling of
RT   Bacteroides fragilis lipopolysaccharide.";
RL   Infect. Immun. 70:4892-4896(2002).
//