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Cellosaurus MCF-10F (CVCL_3633)

[Text version]
Cell line name MCF-10F
Synonyms MCF 10F; MCF10F; MCF-10 Floating; Michigan Cancer Foundation-10F
Accession CVCL_3633
Resource Identification Initiative To cite this cell line use: MCF-10F (RRID:CVCL_3633)
Comments Group: Patented cell line.
Part of: GrayJW breast cancer cell line panel.
Part of: ICBP43 breast cancer cell line panel.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10318.
Doubling time: 47.44 hours (GrayJW panel).
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
HLA typing Source: PubMed=25960936
Class I
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0598 (MCF-10A)
Originate from same individual CVCL_5553 ! MCF-10-2F
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
STR profile Source(s): ATCC


Run an STR similarity search on this cell line
Web pages https://lincs.hms.harvard.edu/resources/reagents/icbp43/

Soule H.D., Maloney T.M., Wolman S.R., Peterson W.D. Jr., Brenz R., McGrath C.M., Russo J., Pauley R.J., Jones R.F., Brooks S.C. Jr.
Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10.
Cancer Res. 50:6075-6086(1990)

Leibovitz A.
Cell lines from human breast.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York (1994)

Soule H.D., McGrath C.M.
Immortal human mammary epithelial cell lines.
Patent number US5436152, 25-Jul-1995

PubMed=12353263; DOI=10.1002/gcc.10107
Popovici C., Basset C., Bertucci F., Orsetti B., Adelaide J., Mozziconacci M.-J., Conte N., Murati A., Ginestier C., Charafe-Jauffret E., Ethier S.P., Lafage-Pochitaloff M., Theillet C., Birnbaum D., Chaffanet M.
Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene.
Genes Chromosomes Cancer 35:204-218(2002)

PubMed=12800145; DOI=10.1002/gcc.10218
Adelaide J., Huang H.-E., Murati A., Alsop A.E., Orsetti B., Mozziconacci M.-J., Popovici C., Ginestier C., Letessier A., Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D., Edwards P.A.W., Chaffanet M.
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Genes Chromosomes Cancer 37:333-345(2003)

PubMed=18056439; DOI=10.1158/0008-5472.CAN-07-1371
Huang Y., Fernandez S.V., Goodwin S., Russo P.A., Russo I.H., Sutter T.R., Russo J.
Epithelial to mesenchymal transition in human breast epithelial cells transformed by 17beta-estradiol.
Cancer Res. 67:11147-11157(2007)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

Cell line collections (Providers) ATCC; CRL-10318
Cell line databases/resources CLO; CLO_0007600
LINCS_HMS; 50584
Anatomy/cell type resources BTO; BTO:0003900
Chemistry resources PharmacoDB; MCF10F_893_2019
Encyclopedic resources Wikidata; Q54904300
Gene expression databases GEO; GSM115080
GEO; GSM115081
GEO; GSM115082
GEO; GSM1172974
GEO; GSM1172883
Polymorphism and mutation databases Cosmic; 1136377
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number31