ID   MCF-10F
AC   CVCL_3633
SY   MCF 10F; MCF10F; MCF-10 Floating; Michigan Cancer Foundation-10F
DR   BTO; BTO:0003900
DR   CLO; CLO_0007600
DR   ATCC; CRL-10318
DR   Cosmic; 1136377
DR   GEO; GSM115080
DR   GEO; GSM115081
DR   GEO; GSM115082
DR   GEO; GSM1172974
DR   GEO; GSM1172883
DR   LINCS_HMS; 50584
DR   PharmacoDB; MCF10F_893_2019
DR   Wikidata; Q54904300
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RX   Patent=US5436152;
RX   PubMed=1975513;
RX   PubMed=12353263;
RX   PubMed=12800145;
RX   PubMed=18056439;
RX   PubMed=24176112;
RX   PubMed=25960936;
CC   Group: Patented cell line.
CC   Part of: JWGray breast cancer cell line panel.
CC   Part of: ICBP43 breast cancer cell line panel.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10318.
CC   Doubling time: 47.44 hours (JWGray panel).
CC   HLA typing: A*01:01,33:01; B*40:01,55:01; C*07:02,03:03 (PubMed=25960936).
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
ST   Source(s): ATCC=CRL-10318
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 8,9
ST   D16S539: 11,12
ST   D5S818: 10,13
ST   D7S820: 10,11
ST   TH01: 8,9.3
ST   TPOX: 9,11
ST   vWA: 15,17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_5553 ! MCF-10-2F
SX   Female
AG   36Y
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 32
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RA   Leibovitz A.;
RT   "Cell lines from human breast.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York (1994).
RX   Patent=US5436152;
RA   Soule H.D., McGrath C.M.;
RT   "Immortal human mammary epithelial cell lines.";
RL   Patent number US5436152, 25-Jul-1995.
RX   PubMed=1975513;
RA   Soule H.D., Maloney T.M., Wolman S.R., Peterson W.D. Jr., Brenz R.,
RA   McGrath C.M., Russo J., Pauley R.J., Jones R.F., Brooks S.C. Jr.;
RT   "Isolation and characterization of a spontaneously immortalized human
RT   breast epithelial cell line, MCF-10.";
RL   Cancer Res. 50:6075-6086(1990).
RX   PubMed=12353263; DOI=10.1002/gcc.10107;
RA   Popovici C., Basset C., Bertucci F., Orsetti B., Adelaide J.,
RA   Mozziconacci M.-J., Conte N., Murati A., Ginestier C.,
RA   Charafe-Jauffret E., Ethier S.P., Lafage-Pochitaloff M., Theillet C.,
RA   Birnbaum D., Chaffanet M.;
RT   "Reciprocal translocations in breast tumor cell lines: cloning of a
RT   t(3;20) that targets the FHIT gene.";
RL   Genes Chromosomes Cancer 35:204-218(2002).
RX   PubMed=12800145; DOI=10.1002/gcc.10218;
RA   Adelaide J., Huang H.-E., Murati A., Alsop A.E., Orsetti B.,
RA   Mozziconacci M.-J., Popovici C., Ginestier C., Letessier A.,
RA   Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D.,
RA   Edwards P.A.W., Chaffanet M.;
RT   "A recurrent chromosome translocation breakpoint in breast and
RT   pancreatic cancer cell lines targets the neuregulin/NRG1 gene.";
RL   Genes Chromosomes Cancer 37:333-345(2003).
RX   PubMed=18056439; DOI=10.1158/0008-5472.CAN-07-1371;
RA   Huang Y., Fernandez S.V., Goodwin S., Russo P.A., Russo I.H.,
RA   Sutter T.R., Russo J.;
RT   "Epithelial to mesenchymal transition in human breast epithelial cells
RT   transformed by 17beta-estradiol.";
RL   Cancer Res. 67:11147-11157(2007).
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110;
RA   Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M.,
RA   Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S.,
RA   Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S.,
RA   Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J.,
RA   Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.;
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893;
RA   Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.;
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).