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Cellosaurus 8E5(CEM) (CVCL_3484)

[Text version]
Cell line name 8E5(CEM)
Synonyms 8E5/LAV; 8E5
Accession CVCL_3484
Resource Identification Initiative To cite this cell line use: 8E5(CEM) (RRID:CVCL_3484)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8993.
Population: Caucasian.
Virology: HIV-1 producing cell line.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6244 (CEM A3.01)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3617

Markers:
AmelogeninX
CSF1PO9,11
D5S81812
D7S8209,13
D13S31712,13
D16S53910,13
TH016,7
TPOX8
vWA17,20

Run an STR similarity search on this cell line
Publications

PubMed=3014036; DOI=10.1084/jem.164.1.280; PMCID=PMC2188205
Folks T.M., Powell D., Lightfoote M., Koenig S., Fauci A.S., Benn S., Rabson A.B., Daugherty D., Gendelman H.E., Hoggan M.D., Venkatesan S., Martin M.A.
Biological and biochemical characterization of a cloned Leu-3- cell surviving infection with the acquired immune deficiency syndrome retrovirus.
J. Exp. Med. 164:280-290(1986)

Patent=US4752565
Folks T.M., Powell D.M., Martin M.A.
Cell line producing AIDS viral antigens without producing infectious virus particles.
Patent number US4752565, 21-Jun-1988

Cross-references
Cell line collections (Providers) ATCC; CRL-3617
ATCC; CRL-8993 - Discontinued
BEI_Resources; ARP-95
Cell line databases/resources CLO; CLO_0001521
cancercelllines; CVCL_3484
Biological sample resources BioSample; SAMN03471213
Encyclopedic resources Wikidata; Q54605508
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number24