Cell line name |
8E5(CEM) |
Synonyms |
8E5/LAV; 8E5 |
Accession |
CVCL_3484 |
Resource Identification Initiative |
To cite this cell line use: 8E5(CEM) (RRID:CVCL_3484) |
Comments |
Group: Patented cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8993. Population: Caucasian. Virology: HIV-1 producing cell line. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_6244 (CEM A3.01) |
Sex of cell |
Female |
Age at sampling |
3Y11M |
Category |
Cancer cell line |
STR profile |
Source(s): ATCC=CRL-3617
Markers: Run an STR similarity search on this cell line |
Publications | PubMed=3014036; DOI=10.1084/jem.164.1.280; PMCID=PMC2188205 Folks T.M., Powell D., Lightfoote M., Koenig S., Fauci A.S., Benn S., Rabson A.B., Daugherty D., Gendelman H.E., Hoggan M.D. Jr., Venkatesan S., Martin M.A. Biological and biochemical characterization of a cloned Leu-3- cell surviving infection with the acquired immune deficiency syndrome retrovirus. J. Exp. Med. 164:280-290(1986) Patent=US4752565 Folks T.M., Powell D.M., Martin M.A. Cell line producing AIDS viral antigens without producing infectious virus particles. Patent number US4752565, 21-Jun-1988 |
Cross-references |
Cell line collections (Providers) |
ATCC; CRL-3617
ATCC; CRL-8993 - Discontinued
BEI_Resources; ARP-95
|
Cell line databases/resources |
CLO; CLO_0001521
cancercelllines; CVCL_3484
|
Biological sample resources |
BioSample; SAMN03471213
|
Encyclopedic resources |
Wikidata; Q54605508
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 19-Dec-2024 |
Version number | 24 |
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